GTU B.Pharm 2019 Winter Question Papers || Gujarat Technological University
Subject Name: PHARMACEUTICAL CHEMISTRY-X (MEDICINAL CHEMISTRY)
Time: 3 Hours (02.30 PM to 05.30 PM) Total Marks: 80
| Seat No.: | Enrolment No. |
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm — SEMESTER 8 EXAMINATION — WINTER -2019
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Subject Code:280003 Date: 19/11/2019Subject Name: PHARMACEUTICAL CHEMISTRY-X (MEDICINAL CHEMISTRY)
Time: 3 Hours (02.30 PM to 05.30 PM) Total Marks: 80
Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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| Q.1 | (a) Write a note on Hansch Linear Free Energy Relationship (LFER) Model in QSAR Studies | 06 |
| (b) Discuss direct and indirect Molecular modeling | 05 | |
| (c) Write a note on high throughput screening (HTS) | 05 | |
| Q.2 | (a) Give SAR activity of Dihydropyridines and Give the synthesis of Nifidipine | 06 |
| (b) Give synthesis of any two: a) Metformin b) Glipizide c) Carbimazole | 05 | |
| (c) Outline SAR activity of 5- Sulfamoyl benzoic acid derivatives | 05 | |
| Q.3 | (a) Define and classify diuretics with suitable examples. Discuss Potassium Sparing Diuretics | 05 |
| (b) Write a note anti anginal drugs | 05 | |
| (c) Give structure and synthesis of: 1) Clofibrate b) Warfarin | 06 | |
| Q.4 | (a) Write a brief note on Physico Chemical Properties affecting drug action | 05 |
| (b) Write mechanism of action, uses, side effect and SAR of ACE Inhibitors | 05 | |
| (c) Write a short note on sodium channel blockers as anti hypertensive | 06 | |
| Q.5 | (a) Define Atherosclerosis and classify Antihyperlipidemic agents. Give normal value of LDL; HDL, Triglycerides and Total cholesterol levels | 05 |
| (b) Sketch out the process of blood clotting schematically and discuss on the intervention part of anticoagulants | 05 | |
| (c) Give structure of: a) spironolactone b) Procainamide c) Hydralazine d) Acetazolamide | 05 | |
| Q.6 | (a) Define anti arrhythmic drugs. Give a comprehensive account of antiarrythmic agents used as CVS Drugs with one example in each category | 06 |
| (b) What are calcium channel blockers, classify them and give synthesis of of atenolol | 05 | |
| (c) Discuss chemistry and SAR of cardiac glycoside | 05 | |
| Q.7 | (a) Give brief account of beta blockers as potential antihypertensive agents. | |
| (b) Classify diuretics give mechanism and structure of one drug from each class. | ||
| (c) Write a note on anti obesity drugs |
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