Seat No.:
Subject Code: BP202TP
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Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 2 EXAMINATION - SUMMER -2019
Subject Name: Pharmaceutical Organic Chemistry I
Time: 10:30 AM TO 01:30 PM
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Date: 29-05-2019
Total Marks: 80
Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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Q.1 (a) Give IUPAC name of followings: 06
A) /?)k B) © Br o O\C/NH, . D)//J\\T//“\\F/JL\H E) F) P ” J (b) Write all possible isomers of C4Hg and name them by IUPAC system. 05 --- Content provided by FirstRanker.com --- (c) Define and classify organic compound. Explain SP* hybridization of alkane. 05 Q.2 (a) Give the structure and uses of the following 06 (1) Chlorobutanol (2) Methyl salicylate (3) Hexamine (4) Vanillin (5) Paraldehyde (6) Ethylenediamine (b) Describe effect of substituent on'basicity of aliphatic amine. Why 2° amine is 05 more basic than 1° and 3° amine in aqueous media? --- Content provided by FirstRanker.com --- (c) Give three methods for synthesis of alkenes. 05 Q.3 (a) Explain reaction mechanism of cannizzaro reaction and perkin condensation. 06 (b) Explain acidity of carboxylic acid in brief. What is the impact on acidity of 05 benzoic acid if it was substituted with —OH or —CH3? (c) Mention method of preparation for carboxylic acid. Give any two qualitative 05 tests for identification of carboxylic acid. Q.4 (a) Write Aldol condensation & Cross aldol condensation with reaction mechanism. 06 --- Content provided by FirstRanker.com --- (b) Explain method for synthesis of alkyl halides. 05 (c) Describe the factors affecting the E1 and E2 reaction. 05 Q.5 (a) Give general mechanism for nucleophilic addition of carbonyl compounds. 06 Mention any three nucleophilic addition reactions of aldehyde or ketone. (b) Explain ozonolysis of alkene in detail. 05 (c) Describe stability of conjugated dienes. 05 --- Content provided by FirstRanker.com --- Q.6 (a) Differentiate Markownikoff’s addition and Anti-markownikoff’s addition to 06 alkene. (b) Explain Saytzeff rule with examples. 05 (c) What is pyrolysis? Give general reaction of pyrolysis for alkane. 05 Q.7 (a) How will you distinguish 1°, 2° and 3° alcohol? Explain Grignard reaction for 06 synthesis of alcohols. (b) Write note on Diel-Alder reaction. 05 --- Content provided by FirstRanker.com --- (c) Write short notes. 05
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