Download GTU B.Pharma 2019 Summer 3rd Sem 230002 Pharmaceutical Engineering Ii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 3rd Sem 230002 Pharmaceutical Engineering Ii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 3 EXAMINATION ? SUMMER -2019
Subject Code: 230002 Date: 01-06-2019
Subject Name: Pharmaceutical Engineering - II
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Define flow properties. Discuss about importance of powder flow in
06
pharmaceuticals

(b) Explain Carr's Index / Compressibility index and give the pharmacopoeial
05
specifications for it.

(c) Discuss on methods used for measurement of Angle of repose.
05



Q.2 (a) Discuss about uses of various excipients in different pelletization technique.
06

(b) Discuss techniques to improve powder flow.
05

(c) What is the importance of control charts in pharmaceutical processings
05



Q.3 (a) What is supercritical fluid? Enlist application of SCF
06

(b) What is Rapid Expansion of Supercritical Solution (RESS) technique?
05

(c) Explain various processes and equipments used in supercritical fluid application.
05



Q.4 (a) Draw schematic diagram of control chart and describe elements of control chart.
06

(b) Explain C chart and P chart for attributes.
05

(c) What are the advantages and limitations of Carbon dioxide as SCF?
05



Q.5 (a) Define extrusion and spheronization. Discuss about production of pellets by
06
extrusion-spheronization

(b) Short note on M.C.C in pelletization.
05

(c) Write a note on Hot melt extrusion
05



Q. 6 (a) Define content uniformity.What are different sampling techniques for content
06
uniformity test?

(b) Explain the rate holing and arching. Discuss its cases and remedies.
05

(c) Compare and contrast: Uniformity of dosage as per IP and USP.
05



Q.7 (a) Give Comment on-Supercritical fluid can improve bioavailability through
06
dissolution enhancement.

(b) Discuss factors affecting pellet properties.
05

(c) What are the regulatory requirements for weight variation test for solid dosage
05
form as per IP.
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