Download GTU B.Pharma 2019 Summer 3rd Sem BP301TP Pharmaceutical Organic Chemistry Ii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 3rd Sem BP301TP Pharmaceutical Organic Chemistry Ii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 3 EXAMINATION ? SUMMER -2019
Subject Code: BP301TP Date: 28-05-2019
Subject Name: Pharmaceutical Organic Chemistry II
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Explain molecular orbital structure and resonance energy of benzene.
06

(b) Explain effect of substituent on acidity of benzoic acid.
05

(c) Notes on Sachse Mohr's theory.
05



Q.2 (a) Why benzene undergoes electrophilic substitution reaction? Explain
06
halogenation reaction of benzene with mechanism.

(b) Write down important reaction involve in benzoic acid in detail.
05

(c) Discuss about reaction of cyclopropane and cyclobutane.
05



Q.3 (a) Notes on Haworth synthesis for naphthalene and Anthracene.
06

(b) Discuss about Coulson and Moffitts modification of cycloalkanes.
05

(c) Write down structure and medicinal use of Anthracene, diphenylmethane
05
triphenylmethane derivatives.



Q.4 (a) Write a notes on acidicity and effect of substituents of phenol.
06

(b) Discuss the molecular orbital structure of naphthalene?
05

(c) What happen when
05
(a) Naphthalene is treated with concentrated sulphuric acid at 1650C.
(b) Anthracene is treated with sodium dichromate and sulphuric acid.



Q.5 (a) Write down significance and principle involve in determination of
06
(a) RM value (b) Acetyl value
(c) Ester value (d) Iodine value

(b) Notes on synthetic use of aryl diazonium salts.
05

(c) Explain
05
(a) Why phenol is more acidic than ethyl alcohol?
(b) Why o-nitrophenol is steam volatile whereas p-nitrophenol is not?



Q. 6 (a) How will you synthesise the following compounds from benzene
06
(a) Benzene hexachloride (b) Ethylbenzene
(c) Isopropylbenzene (d) Cyclohexane

(b) Write down structure and use of following compounds
05
(a) DDT (b) Saccharin (c) Cresol

(c) Notes on inductive group and its directing effect in monosubstituated benzene.
05



Q.7 (a) Explain hydrogenation of oil with diagram. Discuss significance and principal
06
of acid value and saponification value.

(b) Notes on a Fridel crafts alkylation and acylation of benzene
05

(c) Discuss Bayer's strain theory with suitable examples.
05
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