Download GTU B.Pharma 2019 Summer 4th Sem 2240004 Pharmaceutical Chemistry Vi (Organic Chemistry Ii) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 4th Sem 2240004 Pharmaceutical Chemistry Vi (Organic Chemistry Ii) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 4 EXAMINATION ? SUMMER -2019
Subject Code: 2240004 Date: 15-05-2019
Subject Name: Pharmaceutical Chemistry ? VI (Organic Chemistry ? II)
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Define the following terms.
06
i.
Enantiomer
ii.
Diastereomer
iii.
Atropisomers
iv.
Absolute configuration
v.
Racemic mixture
vi.
Geometric isomers

(b) Write a note on resolution of racemic mixture.
05

(c) Explain in brief about stereochemistry of biphenyls.
05



Q.2 (a) Write a note on Sandmeyer reaction.
06

(b) write a note on Kolbe reaction.
05

(c) Explain the synthesis of phenol from cumene.
05



Q.3 (a) Complete the following reactions.
06
C H MgBr
2
5
H+
?
?
H O
2
NH3
H+
?
?
H O
2
HNO2
CuCN
?
?
5-10 C

(b) Write a note on Hoffmann degradation of amides.
05

(c) Write a short note on benzyne mechanism for nucleophilic aromatic
05
substitution.



Q.4 (a) Enumerate different methods for preparation of carboxylic acids and explain
06
oxidation reactions to prepare carboxylic acid.

(b) Give the R & S configuration of following compounds.
05
COOH
CHO
CHO
H
NH
H
OH
H
Br
2
CH OH
CH CH
COOH
2
2
3

(c) Write a note on acidity of carboxylic acid and effect of substituents on acidity.
05

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Q.5 (a) Write a note on aldol condensation.
06

(b) Give the different reactions of carboxylic acids.
05

(c) Write down the properties and preparations of indole.
05



Q. 6 (a) Give the preparation and properties of Pyridine.
06

(b) Give any two methods for preparation of quinoline.
05

(c) Write a note on microwave synthesis.
05



Q.7 (a) Answer the following questions.
06
i. Justify: imidazole is basic.
ii. Justify: furan is aromatic.

(b) Give the structure of following ring systems.
05
i.
Thiophene
ii.
Isoquinoline
iii.
Pyrimidine
iv.
Oxazole
v.
Isothiazole

(c) Write in detail about principles of green chemistry.
05
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