Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER- 4 EXAMINATION - SUMMER -2019Subject Code: 2240005 Date: 06-05-2019
Subject Name: Basic Concepts of Pharmacology and Clinical Pharmacy Practice
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Define Phase I &Phase II reactions. Explain Phase II reactions. 06
(b) Write a note on volume of distribution. 05
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(c) Define terms: poison, tachyphylaxis, biological half life, pharmacokinetics, and synergism. 05
Q.2 (a) Explain in brief, mechanisms of drug transport across the cell membrane. 06
(b) Enlist various routes of administration. Discuss advantages and disadvantages of oral route. 05
(c) Write a note on therapeutic drug monitoring. 05
Q.3 (a) Discuss factors affecting modification of drug effects in elderly population. 06
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(b) Give targets for drug action and explain principles of drug action. 05
(c) Explain bioavailability and bioequivalence. 05
Q.4 (a) Discuss functions and targets for drug action for G- protein coupled receptors. 06
(b) Write a note on nuclear receptors giving examples of drugs. 05
(c) Explain dose response relationship. 05
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Q.5 (a) Classify drug interactions according to M/A and explain drug — food interactions. 06
(b) Discuss different aspects to be considered for effective patient counseling. 05
(c) Write a note on Medication errors. 05
Q.6 (a) Classify adverse drug reactions and write on type B ADRs. 06
(b) What is EMLE. Discuss advantages and disadvantages of essential medicines. 05
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(c) Discuss the role of drug and therapeutic committee. 05
Q.7 (a) Detail on rational use of medicine. 06
(b) Explain drug antagonism. 05
(c) Write a note on penetration of drugs in brain. 05
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