Download GTU B.Pharma 2019 Summer 4th Sem 240004 Pharmaceutical Analysis Ii Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 4 EXAMINATION - SUMMER -2019
Subject Code: 240004 Date: 13-05-2019
Subject Name: Pharmaceutical Analysis - 11
Time: 10:30 AM TO 01:30 PM Total Marks: 80

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Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. (a) What are different retention mechanisms in chromatography? Elaborate any two in detail. 05
   

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   (b) Discuss the various development techniques of paper chromatography 05
   (c) Discuss Van Deemter equation in detail. 06
2. (a) Explain validation and describe the validation of instrumental analytical methods. 05
   (b) What is S/N ratio? explain sources of noise in instrumental analysis 05
   (c) Discuss advantages and limitations of instrumental analysis. 06

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3. (a) Write working principle of glass electrode. Write the disadvantage of use of glass electrode. 05
   (b) Discuss the various types of potentiometric titrations. And discuss any one in detail. 05
   (c) Discuss membrane electrodes in detail. 06
4. (a) Define conductance. Describe the applications of conductometry. 05
   (b) Describe factors affecting conductance. 05
   

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   (c) Explain conductometric titration curve for weak acid against strong base with suitable example. 06
5. (a) Describe the working of DME. And discuss the advantages and disadvantages of DME. 05
   (b) Define:
   1. R_f 2. Diffusion current. 3. Residual current 4. Resolution 5. HETP 05
   (c) Distinguish the following pairs:
   

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   1. Normal phase and reverse phase chromatography
   2. Equivalent conductance and specific conductance. 06
6. (a) Define thermogravimetry and classify them, discuss factors affecting thermogravimetric curve. 05
   (b) What is difference between DSC and DTA? Write applications of both. 05
   (c) Discuss instrumentation of Polarimeter. 06

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7. (a) Write note on following :
   (1) Amperometric titration
   (2) Half wave potential 05
   (b) Write a note on differential pulse polarography. 05
   (c) Write comment on following
   

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   (1) Stripping voltametry has high sensitivity.
   (2) Supporting electrolytes are used in polarography.
   (3) Zinc silicate is used in TLC 06

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