Download GTU B.Pharma 2019 Summer 4th Sem 240005 Pharmacology I Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 4th Sem 240005 Pharmacology I Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 4 EXAMINATION ? SUMMER -2019
Subject Code: 240005 Date: 15-05-2019
Subject Name: Pharmacology - I
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a)
Explain the following terms:
06
i.
Teratogenicity
ii.
Structure activity relationship

(b)
Write a short note on local anesthetics.
05

(c)
Describe the pharmacological and physiological role of serotonin.
05



Q.2 (a)
Explain Dose response relationship and its importance.
06

(b)
Briefly explain various types of animal toxicity studies.
05

(c)
Classify sympathomimetic drugs.
05



Q.3 (a)
Define biotransformation. Describe enzyme induction and enzyme inhibition 06
with examples.

(b)
Explain signal transduction mechanism of G-protein coupled receptors.
05

(c)
Explain in detail about anticholinesterase poisoning and its treatment.
05



Q.4 (a)
Enumerate routes of drug administration. Give the merits and demerits of 06
intravenous route of drug administration.

(b)
Explain drug antagonism. Give difference between competitive and non- 05
competitive antagonism with suitable examples

(c)
Write a short note on drugs acting on autonomic ganglia.
05



Q.5 (a)
Describe in short on the following
06
i.
Prostaglandins
ii.
Histamine

(b)
Give difference between non depolarizing agents and depolarizing agents as 05
neuromuscular blockers.

(c)
Explain plasma protein binding of drugs and its clinically significant 05
implications with suitable examples.



Q. 6 (a)
Classify muscarinic and nicotinic receptors with subtypes and explain 06
pharmacological action of Acetylcholine.

(b)
Define drug and explain different sources of drugs
05

(c)
Write a short note on bioavailability
05



Q.7 (a)
Write a short note on neurohumoral transmission.
06

(b)
Explain drug tolerance and dependence.
05

(c)
Write a short note on phases of clinical trials.
05
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