Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER- 4 EXAMINATION - SUMMER -2019
Subject Code: BP402TP Date: 09-05-2019
Subject Name: Medicinal Chemistry I
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Define: Chelation, Bioisosterism, Partition coefficient, Ionization, Optical isomerism, Hydrogen bonding 06
(b) Define Xenobiotics. Give importance of CYP-450 in drug metabolism. 05
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(c) What are Sympathomimetic agents? Classify them with examples. 05
Q.2 (a) Enlist different pathways of drug metabolism. Describe any two conjugation reaction in drug metabolism giving specific examples. 06
(b) Explain: Biosynthesis and catabolism of catecholamine. 05
(c) Give the synthesis and uses of following drugs: 05
- Carbamazepine
- Dicyclomine HCl
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Q.3 (a) Write a note on parasympatholytic agents. 06
(b) Give SAR of Benzodiazepines. 05
(c) What are antipsychotics drugs? Write: SAR of phenothiazines. 05
Q.4 (a) What are NSAIDs? Classify them with two examples of each class. Write synthesis of one NSAID having one chiral center. 06
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(b) Classify General anesthetics and give synthesis of Halothane. 05
(c) Give the structures of following drugs: 05
- Scopolamine Hydrobromide
- Paraldehyde
- Pentazocine
- Oxazepam
- Secobarbital
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Q.5 (a) Write a note on Narcotic antagonists with its mechanism. 06
(b) Explain in details: Factor affecting drug metabolism including stereo chemical aspects. 05
(c) Give the synthesis and uses of following drugs: 05
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- Methohexital sodium
- Methadone HCl
Q.6 (a) Define Insomnia. Explain mechanism and SAR of Barbiturates. 06
(b) Explain stages of anesthesia with classification of Inhalation anesthetics. 05
(c) Write a note on Fluro buterophenones with its mechanism. 05
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Q.7 (a) Classify anticonvulsants with its mechanism and SAR. 06
(b) Give SAR of Morphine analogues. 05
(c) Give the structures of following drugs: 05
- Chlorprothixene
- Clonazepam
- Valproic acid
- Glutethmide
- Carvedilol
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