Seat No.:
Subject Code: BP403TP
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Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 4 EXAMINATION - SUMMER -2019
Subject Name: Physical Pharmaceutics 1T
Time: 10:30 AM TO 01:30 PM
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Total Marks: 80
Date: 13-05-2019
Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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- (a) Discuss pharmaceutical application of colloids. Differentiate various types of colloidal dispersion system. (06)
- (b) Explain: Kraft point and gold number. (05)
- (c) Explain kinetic properties of colloids. (05)
- (a) Discuss the concept of DLVO theory along with the energy curve and explain how this theory is applied in stabilizing the colloidal dispersion. (06)
- (b) What is the effect of plug flow in measurement of viscosity of a plastic system, in cup and bob viscometer? How plug flow can be minimised? (05)
- (c) Write a note on thixotropy. (05)
- (a) Discuss non-Newtonian flow with rheogram, mechanism and explain with suitable example. (06)
- (b) Describe a suitable viscometer with diagram which can measure the viscosity of dispersion of sodium alginate in water. (05)
- (c) Define suspension. Differentiate between flocculated and deflocculated suspension. (05)
- (a) Discuss different approaches used to achieve flocculation in suspensions. (06)
- (b) Explain sedimentation parameter of suspension in detail. (05)
- (c) Enlist the physical instability markers of emulsion and discuss any two. (05)
- (a) Enlist the different type of densities of powder. Write the experimental method for the determination of true density. (06)
- (b) Explain method for determining particle surface area. (05)
- (c) Give factors affecting powder flow. (05)
- (a) Enlist methods of particle size estimation. Explain conductivity method in detail. (06)
- (b) Discuss angle of repose and Carr’s Index with their pharmacopoeial specification. (05)
- (c) Write a short not on accelerated stability study. (05)
- (a) Describe the various methods of determination of reaction order. (06)
- (b) Explain factors which govern the rate of chemical reaction. (05)
- (c) Discuss the various means of stabilization of product which is sensitive to oxidation. (05)
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