Download GTU B.Pharma 2019 Summer 5th Sem 2250004 Pharmaceutical Chemistry Vii (Medicinal Chemistry I) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 5th Sem 2250004 Pharmaceutical Chemistry Vii (Medicinal Chemistry I) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 5 EXAMINATION ? SUMMER -2019
Subject Code: 2250004 Date: 03-06-2019
Subject Name: Pharmaceutical Chemistry ? VII (Medicinal Chemistry - I)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss the following physicochemical parameters in relation to biological
06
activity
(i)
Protein binding (ii) Solubility

(b) Write briefly about Bioisosterism.
05

(c) Explain how optical isomerism affects drug action.
05



Q.2 (a) Define expectorants, Antitussives and respiratory stimulants with examples.
06

(b) Explain antiasthmatics in detail.
05

(c) Write short notes on Prokinetics.
05



Q.3 (a) Discuss Antisecretary agents and proton pump inhibitors.
06

(b) Give IUPAC name and synthesis of the following drugs :
05
(i)
Ranitidine (ii) Omeprazole

(c) Explain the followings with examples ;
05
(i)
Antispasmodics (ii) Drugs for IBS



Q.4 (a) Write IUPAC name and synthetic routes of the following drugs :
06
(i)
Chorcyclizine (ii) Promethazine
(iii) Cyproheptadine

(b) What are H1 receptor antagonists. Classify them with examples.
05

(c) What are eicosanoids ? Write briefly about biosynthesis of Prostaglandins.
05



Q.5 (a) Write short notes on Radiopharmaceuticals as diagnostic agents.
06

(b) Write ideal properties of Antacids.
05

(c) Write in detail about Antidiarrheal agents.
05



Q. 6 (a) Write SAR of muscarinic antagonists.
06

(b) Explain Neuromuscular blocking agents.
05

(c) Write short notes on
05
(i)
- blockers (ii) Hydrogen bonding and drug action



Q.7 (a) Write IUPAC name and synthesis of
06
(i)
Propranolol (ii) Adrenaline
(ii)
Diatrizoic acid

(b) Give SAR of Parasympathomimetics.
05

(c) Write short notes on antiemetics.
05
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