Download GTU B.Pharma 2019 Summer 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Summer 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER? 5 EXAMINATION ? SUMMER -2019
Subject Code: 250004 Date: 03-06-2019
Subject Name: Pharmaceutical Chemistry - VI (Medicinal)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) What are proton pumps inhibitors? Explain its mechanism of action. Sketch the
06
important steps involved in synthesis of Omeprazole.

(b) Write a note on antitussive agents.
05

(c) How does protein binding affect biological activity?
05



Q.2 (a) Give structure, IUPAC name and synthesis of following compounds.
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1. Cetrizine 2. Chlorpheniramine

(b) Give reactions of Pyrrole.
05

(c) Write about effect of hydrogen bonding and stereoisomerism on biological
05
activity.



Q.3 (a) Give preparations of Furan.
06

(b) What is peptic ulcer? Give brief note on H2-antagonists.
05

(c) Write in detail about the chemistry of prostaglandins.
05



Q.4 (a) Explain following terms with examples 1. Prokinetics 2. Laxatives 3. Irritable
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bowel syndrome.

(b) Define antihistaminic agents and write SAR of H1 receptor blockers.
05

(c) Write down various reactions of Thiazole and Imidazole.
05



Q.5 (a) Write structure and IUPAC name of Diphenhyramine, Doxylamine and
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Chlorcyclizine.

(b) Discuss reactivity of pyridine towards electrophiles and nucleophiles.
05

(c) Explain the physicochemical parameters affecting drug absorption.
05



Q. 6 (a) Classify antiasthmatic agents and discuss about bronchodilators.
06

(b) Give preparation of Quinoline.
05

(c) Write a note on mucolytic agents.
05



Q.7 (a) Write structure and IUPAC name of Salbutamol, Bromhexine and
06
Nikethamide.

(b) Write a note on antidiarrheals.
05

(c) Write a note on radiological contrast media. Give synthesis of Diatriazoic acid.
05
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