GTU B.Pharm 2019 Summer Question Papers || Gujarat Technological University
Seat No.:
Subject Code: 2280003
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Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 8 EXAMINATION - SUMMER -2019
Subject Name: Pharmaceutical Chemistry — X (Medicinal Chemistry - III)
Time: 10:30 AM TO 01:30 PM
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
| Q.1 | (a) | Define and classify Antihyperlipidemic agents. Give the structural formula of any three drugs belonging to different class. | 06 |
| (b) | Discuss the SAR of HMG CoA Reductase inhibitors. | 05 | |
| (c) | Write short notes on heparin as anticoagulant. | 05 | |
| Q.2 | (a) | Classify Antiarrhythmic agents with one structure in each class. Write synthesis of Lignocaine. | 06 |
| (b) | Discuss Plasma expanders in detail. | 05 | |
| (c) | Write short notes on sodium channel blockers as antiarrhythmic agents. | 05 | |
| Q.3 | (a) | Classify diuretics with one structure in each class. Write mechanism of action, uses and side effect of spironolactone. | 06 |
| (b) | Give SAR of thiazide diuretics. | 05 | |
| (c) | Write a note on Antiobesity Drugs. | 05 | |
| Q.4 | (a) | Define and classify antidiabetic agents. Give the synthesis of Metformin. | 06 |
| (b) | Write a short note on Adrenocorticoids. | 05 | |
| (c) | Explain in detail the nomenclature and stereochemistry of steroidal compounds. | 05 | |
| Q.5 | (a) | Define and classify cardiotonics with examples. Give SAR of Cardiac glycosides. | 06 |
| (b) | Discuss SAR of ACEinhibitors. | 05 | |
| (c) | Give the synthesis and uses of the following: (Any two) --- Content provided by FirstRanker.com --- (1) Methimazole (ii) Dobutamine (iii) Atenolol | 05 | |
| Q.6 | (a) | Write informative note on Antiplatelet agents. | 06 |
| (b) | Discuss SAR of estrogens. | 05 | |
| (c) | Write a detailed note on Immunomodulators. | 05 | |
| Q.7 | (a) | What are androgens? Give their SAR and brief idea about anabolic agents. | 06 |
| (b) | Give synthesis of hydrochlorthiazide and Furosemide. | 05 | |
| (c) | Give synthesis of glyceryltrinitrate and Nifedipine. | 05 |
Total Marks: 80
Date: 10-05-2019
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