GTU B.Pharm 2019 Summer Question Papers || Gujarat Technological University
Seat No.:
Subject Code: 2280008
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Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 8 EXAMINATION - SUMMER -2019
Subject Name: Bioavailability and Therapeutic Drug Monitoring
Time: 10:30 AM TO 01:30 PM
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
- (a) Explain Relative and absolute bioavailability. (06)
- (b) What is bioequivalence? Describe first pass clearance. (05)
- (c) Write Objectives of BA studies. (05)
- (a) Describe physicochemical and formulation related Factors affecting bioavailability. (06)
- (b) Discuss Pharmacodynamic and pharmacokinetic models. (05)
- (c) Write note on Theories of dissolution. (05)
- (a) Explain Study designs and analysis of BA-BE studies. (06)
- (b) Write note on In vivo - In vitro correlation studies. (05)
- (c) Describe various Techniques for enhancing Bioavailability. (05)
- (a) Explain recommendations and uses of TDM. (06)
- (b) Describe Methods and parameters of assessing bioavailability. (05)
- (c) Write criteria for selection of method for TDM. (05)
- (a) Write techniques used for estimation of addictive drugs. (06)
- (b) Explain Problems of interference of biological matrix. (05)
- (c) Write note on Sample preparation. (05)
- (a) Discuss various Techniques used in TDM. (06)
- (b) Write short note on RIA. (05)
- (c) Describe Immunoassays. Explain ELISA in detail. (05)
- (a) Discuss clinical monitoring and dosing parameter techniques for Gentamicin. (06)
- (b) Write note on TDM of theophylline. (05)
- (c) Explain Collection and storage of samples of body fluids. (05)
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Total Marks: 80
Date: 18-05-2019
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