Seat No.:
Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 8 EXAMINATION - SUMMER -2019
Subject Code: 280003 Date: 10-05-2019
Subject Name: Pharmaceutical Chemistry-X (Medical Chemistry)
Time: 10:30 AM TO 01:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) What are Antihypertensive agents? Classify them in detail. 06
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(b) Give SAR of cardiac glycosides. 05
(c) Write synthesis of Carvedilol and Captopril. 05
Q.2 (a) Give SAR of dihydropyridines. Give examples of two such drugs. 06
(b) What is the difference between cardenolides & bufadienolides? 05
(c) Name the drug which is synthesised by Hantzsch synthesis. 05
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Q.3 (a) What is the full form of ACE? Give the pathway of ACE inhibition by drugs. 05
(b) What is flecainide and how it is synthesised? 05
(c) Define angina. How it can be controlled? 06
Q.4 (a) Give SAR of HMGCoA reductase inhibitors. 05
(b) How bile acid sequestering agents act? 05
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(c) Write synthesis of warfarin. How it acts? 05
Q.5 (a) Write a note on thrombolytic agents & plasma expanders. How they act? 05
(b) What are carbonic-anhydrase inhibitors? How they act? Give examples and structure of two drugs. 06
(c) How Free Wilson Mathematical Model helps in drug design? 05
Q.6 (a) Define Diuretic agents? Write SAR of thiazide diuretics. 05
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(b) Write synthesis of furosemide and Ethacrinic acid. 06
(c) Define CADD. Give its importance. 05
Q.7 (a) Write a note on anti obesity drugs. How the drugs reduce lipids? 05
(b) Write a note on Optimization of lead. 06
(c) Explain in detail combinatorial synthesis & parallel synthesis. 05
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This download link is referred from the post: GTU B.Pharma 2018 Summer Question Papers || Gujarat Technological University
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