Download GTU B.Pharma 2018 Winter 3rd Sem 230002 Pharmaceutical Engineering Ii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 3rd Sem 230002 Pharmaceutical Engineering Ii Previous Question Paper

Seat No.: ________
Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 3- EXAMINATION ?WINTER - 2018

Subject Code: 230002
Date: 06/12/2018
Subject Name: Pharmaceutical Engineering - II
Time: 10:30 AM TO 01:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Define content uniformity. Discuss its importance in pharmaceutical dosage
06
forms.

(b) Describe factors affecting achieving content uniformity.
05

(c) Discuss error occur in control chart.
05



Q.2 (a) Enumerate different types of charts. Explain any one in details.
06

(b) Write a note on elements of control charts.
05

(c) Write a note on requirements of regulatory agencies (FDA, USP and EP) for
05
content uniformity.



Q.3 (a) What is importance of powder flow? Discuss factor influencing on powder
06
flow.

(b) Explain the various methods for measurement of angle of repose.
05

(c) What are the pharmacopoeial specifications for Carr's index, Hausner's ratio
05
and angle of repose?



Q.4 (a) Discuss factors affecting pellet properties.
06

(b) Enlist methods of extrusion. Write a note on Hot Melt Extrusion.
05

(c) Explain spheronization. Discuss in brief stages involved in spheronization
05
process.



Q.5 (a) Write a note on SAS technology.
06

(b) Draw and explain phase diagram shows supercritical region with examples.
05

(c) What are the advantages and limitations of Carbon dioxide as SCF?
05



Q. 6 (a) What are pellets? Write their pharmaceutical application and properties.
06

(b) Differentiate inclusion complex and solid dispersion.
05

(c) Describe the role of microcrystalline cellulose in pelletization.
05



Q.7 (a) Explain the application of supercritical fluid in pharmacy.
06

(b) Explain various processes and equipments used in supercritical fluid
05
application.

(c) Write a note on Rapid Expansion of Supercritical Solution (RESS) technique.
05
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