Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER - 4- EXAMINATION -WINTER - 2018
Subject Code: 240004 Date: 06/12/2018
Subject Name: Pharmaceutical Analysis - 11
Time:02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Explain the following terms in brief: 06
- Validation
- Accuracy
- Signal to Noise ratio
- Cell constant
- Supporting analyte
- Cell potential
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(b) Write detailed note on Kohlrausch’s law along with applications. 05
(c) Explain applications of potentiometry in pharmaceuticals. Enlist the methods to detect 05 the end point in potentiometry.
Q.2 (a) Write the advantages and disadvantages of Instrumental methods of Analysis. Write 06 brief note on different types of instrumental noise.
(b) Differentiate the following pairs: 05
- Stationary Phase and Mobile phase
- Equivalent conductance and specific conductance
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(c) Explain Van Deemter equation. Discuss the factors affecting chromatographic peak 05 broadening.
Q.3 (a) Write note on classification of chromatographic techniques. Enlist the theories of 06 chromatography. Describe any one in detail.
(b) Write a short note on Amperometric titrations. 05
(c) What is standard electrode potential? Describe in detail classification of 05 electroanlaytical methods.
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Q.4 (a) Discuss in detail different components of polarogram. 06
(b) Write detailed note on dropping mercury electrode with well labeled diagram. 05
(c) Describe the factors affecting diffusion current in detail. 05
Q.5 (a) What is calorimetry? Write note on principle and applications of DSC in detail. 06
(b) Write detailed note on instrumentation of polarimetry. 05
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(c) Define optical activity and specific rotation. Explain in detail about qualitative and 05 quantitative applications of polarimetry.
Q.6 (a) What is indicator and reference electrode?. Describe construction, working, 06 advantages, disadvantages of glass electrode in detail.
(b) Write a short note on Thin layer chromatography. 05
(c) Define the following terms 05
- Stripping Voltametry
- Asymmetric factor
- Resolution
- Retention time
- Conductance
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Q.7 (a) Describe principle, advantages, disadvantages, applications of paper chromatography alongwith its various development techniques.
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(b) Describe the factors affecting conductance in detail.
(c) Discuss in detail principle, instrumentation and applications of thermogravimetric 05 analysis.
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