Download GTU B.Pharma 2018 Winter 6th Sem 260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 6th Sem 260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry) Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 6- EXAMINATION ?WINTER - 2018

Subject Code:260004
Date: 29/11/2018
Subject Name: Pharmaceutical Chemistry - VIII (Medicinal Chemistry)
Time:02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Write a note on neuromuscular blocking agents with examples.
06

(b) What are Cholinergics? What are their physiological actions? Give SAR of
05
Acetylcholine.

(c) What are CNS stimulants? Classify them. Give their uses and synthesis of
05
Imipramine.



Q.2 (a) Sketch the steps involved in synthesis of (any three): i) Salbutamol 06
ii) Neostigmine iii) Ephedrine iv) Dopamine

(b) What are opioid analgesics? How do they differ from NSAIDs?
05

(c) Give main points of structure activity relationship of Morphine.
05



Q.3 (a) Sketch the steps involved in synthesis of (any three): i) Procaine ii) Lignocaine
06
iii) Benzocaine iv) Halothane

(b) Write a note on factors affecting drug receptor interaction.
05

(c) What is myasthenia gravis? Write the structures of the drugs used in the
05
treatment of myasthenia gravis.



Q.4 (a) Give the structure and IUPAC nomenclature of (any three): i) Amphetamine
06
ii) Thiopental iii) Ibuprofen iv) Diclofenac

(b) Write a note on antiparkinson drugs.
05

(c) What is xenobiotics ? Explain Phase II reactions with examples.
05



Q.5 (a) Classify the drugs used in epilepsy with examples. Which ring system is
06
common to all of them? Sketch the steps involved in synthesis of Phenytoin.

(b) What is schizophrenia? Explain SAR of Phenothiazine derivatives as CNS
05
depressants.

(c) Write a short note on psychomotor stimulants.
05



Q. 6 (a) Write a note on stereochemical aspects of drug metabolism with examples.
06

(b) Classify hypnotics and sedatives with examples. Give their uses and SAR of
05
barbiturates.

(c) Write a note on adrenergic antagonists.
05



Q.7 (a) What are general anesthetics? How do they act? Give SAR of local anesthetics.
06

(b) Write the advantages of selective COX-2 inhibitors over non-selective
05
NSAIDs. Classify NSAIDs and write mechanism of action of Indomethacin.

(c) Write a short note on narcotic antagonists.
05
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