FirstRanker.com
Firstranker's choice
Seat No.: Enrolment No.
--- Content provided by FirstRanker.com ---
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER - 7- EXAMINATION -WINTER - 2018
Subject Code:2270003 Date: 19/11/2018
Subject Name: Pharmaceutical Chemistry — IX (Medicinal Chemistry - III)
Time:10:30 AM TO 01:30 PM Total Marks: 80
--- Content provided by FirstRanker.com ---
Instructions:
- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
- (a) Classify sulfonamide on the basis of chemical structure and explain biosynthetic pathway leading to THF synthesis with involvement of sulfonamides. 06
- (b) Explain SAR of fluoroquinolones. 05
- (c) Write chemical name and synthesis of sulfacetamide and norfloxacin. 05
- (a) Classify cephalosporin and represent various ring and numbering system of clinically available beta-lactam antibiotic types with examples. 06
- (b) Explain chemical instability of penicillin in detail. 05
- (c) Explain SAR activities of aminoglycoside antibiotics. 05
- (a) Give any three structures of macrolide antibiotics and explain why erythromycin is unstable in acid media. 06
- (b) Explain epimerization and degradation of tetracycline in detail. 05
- (c) Write a short note on carbapenem and monobactams. 05
- (a) Classify antimalarial-agents with examples and structures. 06
- (b) Write chemical name and synthesis of primaquine and metronidazole. 05
- (c) Explain SAR activities of quinolines. 05
- (a) Explain XDR-TB. write a note on first-line anti TB agents. 06
- (b) Classify and explain mechanism of action of azole antifungal agents. 05
- (c) Write chemical name and synthesis of ketoconazole and isoniazid. 05
- (a) What is carcinoma? Classify anticancer agent with examples and structures. 06
- (b) Write a note on alkylating agents used as anticancer agent. 05
- (c) Write a note on antiviral agents. 05
- (a) Explain in detail molecular modeling. 06
- (b) Write a note on methods of lead discovery. 05
- (c) Write a note on QSAR. 05
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
This download link is referred from the post: GTU B.Pharm 2018 Winter Question Papers || Gujarat Technological University
--- Content provided by FirstRanker.com ---