Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER - 7- EXAMINATION -WINTER - 2018
Subject Code:270003 Date: 19/11/2018
Subject Name: Pharmaceutical Chemistry-IX (Medicinal Chemistry)
Time:10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) What are steroids? Give the structural classification of steroids. 06
(b) What are antifungal agents? How do they act? Sketch important steps for synthesis of Ketoconazole. 05
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(c) Classify anti-neoplastic agents and sketch important steps for synthesis of Thiotepa. 05
Q.2 (a) Give IUPAC name and synthesis of (i) Fluorouracil and (ii) Cyclophosphamide. 06
(b) Write the main points elucidating the SAR of Quinolines. 05
(c) Sketch the structures of Nystatin and Amphotericin B. Mention its usage. 05
Q.3 (a) Explain the degradation of Penicillin and write a short note on penicillinase-resistant Penicillins. 06
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(b) Draw chemical structures of iodinated compounds of thyroid glands. 05
(c) What are anabolic agents? Give SAR of testosterone. 05
Q.4 (a) What are Cephalosporins ? How do they differ from penicillins? Give SAR of Cephalosporins. 06
(b) Justify the name “Tetracyclines”. Elucidate its SAR. 05
(c) Write a short note on Rifamycin antibiotics. 05
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Q.5 (a) Give life cycle of malarial parasite. Classify antimalarials with examples. Give synthesis of Primaquine. 06
(b) Sketch the important steps involved in synthesis of Isoniazid and Ethambutol. 05
(c) Write a note on immunomodulators OR Antithyroid drugs. 05
Q.6 (a) Classify Penicillins with examples on the basis of mechanism of action. Why Penicillin is not active against penicillinase secreting microorganisms? 06
(b) Explain the mechanism of action of Co-trimoxazole. Write synthesis of Trimethoprim and Sulfamethoxazole. 05
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(c) Write the mechanism of action, metabolism, SAR and uses of Streptomycin. 05
Q.7 (a) What for are the neuraminidase inhibitors used? Mention its history and development. 06
(b) Give IUPAC name and chemical synthesis of Chloramphenicol. 05
(c) What are Quinolones? Write structure activity relationship of Quinolones. 05
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