Download GTU B.Pharma 2018 Winter 8th Sem 280003 Pharmaceutical Chemistry X (Medical Chemistry) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2018 Winter 8th Sem 280003 Pharmaceutical Chemistry X (Medical Chemistry) Previous Question Paper

Seat No.: ________ Enrolment No.______________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER ? 8- EXAMINATION ?WINTER - 2018

Subject Code: 280003
Date: 19/11/2018
Subject Name: Pharmaceutical Chemistry-X (Medical Chemistry)
Time: 02:30 PM TO 05:30 PM
Total Marks: 80
Instructions:

1. Attempt any five questions.

2. Make Suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Define and classify diuretics. Write a note on loop diuretics.
06

(b) Sketch the important steps in synthesis of (i) Ethacrinic acid (ii) Furosemide.
05

(c) Explain in detail the steric and electronic parameters used in QSAR.
05



Q.2 (a) Write the structure, its ring system, mechanism of action, metabolism and side
06
effects of any one catecholamine depletory used as antihypertensive.

(b) Sketch the important steps in synthesis of (i) Lignocaine (ii) Flecainide.
05

(c) Write a note on arterial and venous vasodilators.
05



Q.3 (a) Define molecular modeling and write a note on application of Computer Aided
06
Drug Design technique.

(b) Outline the SAR of cardiotonics.
05

(c) Define QSAR and write a note on Hansch Linear Free Energy Relationship
05
model.



Q.4 (a) Define antihypertensive agents with its classification and write a note on
06
calcium channel blockers.

(b) Sketch the important steps in synthesis of (i) Captopril (ii) Clofibrate.
05

(c) Explain the SAR of 1, 4-Dihydro pyridines.
05



Q.5 (a) What is Free Wilson Mathematical Model? Explain it.
06

(b) Enlist the centrally acting adrenergic drugs with structures used as
05
antihypertensives.

(c) Enumerate different methods of lead discovery. Write a short note on
05
optimization of lead.



Q. 6 (a) Write a note on plasma volume expanders and antiobesity drugs.
06

(b) What is the mechanism of action and SAR of ACE inhibitors?
05

(c) Define cardiotonic drugs. Write classification with structures.
05



Q.7 (a) Discuss the mechanism of action and SAR of 5-Sulfamoyl benzoic acid
06
derivatives.

(b) Write a note on combinatorial chemistry.
05

(c) Write in detail giving examples the role of antiplatelet agents.
05
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