Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.PHARM - SEMESTER - 8- EXAMINATION ~WINTER - 2018
Subject Code: 280003 Date: 19/11/2018
Subject Name: Pharmaceutical Chemistry-X (Medical Chemistry)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make Suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Define and classify diuretics. Write a note on loop diuretics. (06)
(b) Sketch the important steps in synthesis of (i) Ethacrinic acid (ii) Furosemide. (05)
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(c) Explain in detail the steric and electronic parameters used in QSAR. (05)
Q.2 (a) Write the structure, its ring system, mechanism of action, metabolism and side effects of any one catecholamine depletory used as antihypertensive. (06)
(b) Sketch the important steps in synthesis of (i) Lignocaine (ii) Flecainide. (05)
(c) Write a note on arterial and venous vasodilators. (05)
Q.3 (a) Define molecular modeling and write a note on application of Computer Aided Drug Design technique. (06)
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(b) Outline the SAR of cardiotonics. (05)
(c) Define QSAR and write a note on Hansch Linear Free Energy Relationship model. (05)
Q.4 (a) Define antihypertensive agents with its classification and write a note on calcium channel blockers. (06)
(b) Sketch the important steps in synthesis of (i) Captopril (ii) Clofibrate. (05)
(c) Explain the SAR of 154-Dihydro pyridines. (05)
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Q.5 (a) What is Free Wilson Mathematical Model? Explain it. (06)
(b) Enlist the centrally acting adrenergic drugs with structures used as antihypertensives. (05)
(c) Enumerate different methods of lead discovery. Write a short note on optimization of lead. (05)
Q.6 (a) Write a note on plasma volume expanders and antiobesity drugs. (06)
(b) What is the mechanism of action and SAR of ACE inhibitors? (05)
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(c) Define cardiotonic drugs. Write classification with structures. (05)
Q.7 (a) Discuss the mechanism of action and SAR of 5-Sulfamoyl benzoic acid derivatives. (06)
(b) Write a note on combinatorial chemistry. (05)
(c) Write in detail giving examples the role of antiplatelet agents. (05)
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