Q.P. CODE:M102A030
Dr YSR UNIVERSITY OF HEALTH SCIENCES: VIJAYAWADA- 520008
MBBS DEGREE EXAMINATION - MARCH, 2024
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FIRST M.B.B.S. EXAMINATION
BIOCHEMISTRY - PAPER-I
(Theory Questions)
Time: 2 Hour 40 Minutes
Max Marks: 80
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Note: Answer all questions.
Draw diagrammatic representation wherever necessary
SECTION-II (THEORY QUESTIONS - 80 MARKS)
STRUCTURED ESSAY QUESTIONS: 2 X15 = 30
- A 40-year-old man is brought to the hospital in a comatose state. On examination, he was found to be dehydrated and toxic with a characteristic breathing pattern with sweet smell. He was admitted and investigated. Following are his lab investigations:
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RBS :380 mg/dl
S. HCO3: 15 mEq/L
S. Ketones: 80mg/dl
pH: 7.25
Urinary Benedicts test: ++++--- Content provided by FirstRanker.com ---
Urinary Rothera's test: Positive
Answer the following:- What is your diagnosis?
- What are the favourable points for your diagnosis?
- Explain the metabolism of Ketone Bodies?
- d) Write about the hormonal regulation of blood glucose.
e) What are the differences between types of Diabetes Mellitus? - Define the lipoproteins and classify them. Explain the LDL metabolism. Write about Atherosclerosis.
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SHORT ANSWER QUESTIONS: 10x5=50
- Describe the types of PEM (Protein Energy Malnutrition).
- Define BMR. What is its normal value? What are the factors affecting BMR?
- HMP shunt and its significance.
- What are isoenzymes? Write about cardiac isoenzymes.
- Enumerate the types of Heteropolysaccharides and write their biochemical significance.
- What are antioxidants? Give two examples of:
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Antioxidant enzymes
Antioxidant vitamins
Antioxidant minerals - Write in detail about ETC. Add a note on its inhibition and uncouplers of oxidative phosphorylation.
- What are the factors affecting enzyme activity? Add a note on competitive inhibition.
- What is clearance? What are the different types of clearance tests you know and their significance?
- Describe the steps of heme synthesis. Add a note on AIP (Acute Intermittent Porphyria).
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