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Q.P. CODE: M102A030
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DR NTR UNIVERSITY OF HEALTH SCIENCES : VIJAYAWADA- 520008
MBBS DEGREE EXAMINATION: OCTOBER, 2024
FIRST M.B.B.S. EXAMINATION
BIOCHEMISTRY PAPER-I
(Theory Questions)
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Time: 2 Hour 40 Minutes Max Marks: 80
Note: Answer all questions.
Draw diagrams, representation wherever necessary.
SECTION-II (THEORY QUESTIONS - 80 MARKS)
STRUCTURED ESSAY QUESTIONS: 2x15=30
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- A 50-year-old male attended the casualty department with complaints of chest pain, fatigue, and uneasiness in daily activities. On laboratory examination, the total cholesterol was 293 mg/dl, LDL cholesterol - 160 mg/dl, and his triglycerides were 300mg/dl.
- Write in detail about the types, characteristics, and metabolism of lipoproteins. Add a note on lipoprotein disorders. Describe the chemistry, biochemical functions, daily requirements, sources, and deficiency manifestations of Vitamin A.
SHORT ANSWER QUESTIONS: 10x5=50
- Explain the specificity of an enzyme with examples.
- Describe the electron transport chain. Add a note on inhibitors of ETC.
- Enumerate the types of polysaccharides and their functions.
- Sucrose intolerance.
- Define BMR. What is its normal value? What are the factors affecting BMR?
- A 40-year-old obese woman presented to the medical OPD with a complaint of right upper abdominal pain, mild fever, loss of appetite, and generalized itching. Furthermore, she gave a history of frothy clay-colored stool and high- colored urine. Her lab data is as follows: Total bilirubin - 12 mg%, Direct bilirubin - 10 mg%, Indirect bilirubin - 2 mg%, SGPT - 3 IU/L, SGOT - 50 IU/L, ALP - 350 IU/L.
- What is the probable diagnosis?
- How do you differentiate jaundice based on Vanderberg's reaction?
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- What is clearance? What are the different types of clearance tests you know, and write their importance?
- Describe the metabolic adaptations during starvation.
- Write about the biochemical effects of reactive oxygen species.
- What are isoenzymes? Describe the clinical significance of cardiac isoenzymes.
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