Download NTRUHS 2nd Year MBBS 2022 January Pharmacology Paper I Theory Question Paper

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CBME

Dr YSR UNIVERSITY OF HEALTH SCIENCES: VIJAYAWADA- 520008

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MBBS DEGREE EXAMINATION - JANUARY, 2024

SECOND M.B.B.S. EXAMINATION

PHARMACOLOGY PAPER-I

(Multiple Choice Questions) (SET-D)

Note: Answer all questions.

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SECTION-I (MCQs - 20 MARKS) 1X2=20

1. Which of the following statements is True about plasma protein binding of drugs
   1. Acidic drugs binds to a1- acid glycoprotein
   2. Drugs with high plasma protein binding have high volume of distribution
   3. Dialysis is not useful in poisoning of drugs with high plasma protein binding
   4. Drugs with high plasma protein binding have short duration of action

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2. Glomerular filtration for a drug depends on which of the following
   1. Lipid solubility
   2. Renal blood flow
   3. Efflux pumps
   4. Membrane transporters

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3. Volume of distribution of a drug relates to the ......
   1. Amount of drug in the body to the plasma concentration
   2. Amount of drug cleared from the body per unit time
   3. Volume of plasma in which the drug is distributed
   4. Amount of drug metabolized per unit time

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4. Which of the following enzyme is induced by Rifampicin
   1. CYP3A
   2. CYP2D
   3. CYP2C
   4. CYP2C

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5. Which among the following beta blockers is safe in an asthmatic patient with glaucoma
   1. Betaxolol
   2. Timolol
   3. Propranolol
   4. Nadolol

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6. Vasomotor reversal of dale phenomena is due to
   1. Stimulation of a1 receptor
   2. Blockade of a1 receptor
   3. Stimulation of a2 receptor
   4. Blockade of a2 receptor

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7. Neostigmine does not cross the blood-brain barrier because it is a
   1. Primary amine
   2. Secondary amine
   3. Tertiary amine
   4. Quaternary amine

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8. Why acetylcholine is not used therapeutically
   1. Highly toxic
   2. Drug interactions are more
   3. Short duration of action
   4. Long duration of action

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9. Which of the following adverse effects is seen at toxic concentrations in a patient on treatment with phenytoin
   1. Gum hypertrophy
   2. Hirsutism
   3. Ataxia
   4. Osteomalacia

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10. Which of the following drugs is preferred for a 22-year-old male patient with absence seizures and concomitant generalized tonic-clonic seizures
    1. Valproate
    2. Ethosuximide
    3. Gabapentin
    4. Phenobarbitone

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11. Drug used for the treatment of Morphine overdose
    1. Naltrexone
    2. Clonidine
    3. Neostigmine
    4. Pethidine

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12. The antiviral drug which is also useful to treat Parkinson's disease
    1. Velpatasvir
    2. Amantadine
    3. Oseltamivir
    4. Nevirapine

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13. Which of the following drugs used in heart failure may cause hyperkalemia
    1. Digoxin
    2. Spironolactone
    3. Nifedipine
    4. Furosemide

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14. Coronary steal phenomenon is seen with which of the following drugs
    1. Diltiazem
    2. Dipyridamole
    3. Atenolol
    4. Nifedipine

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15. A patient on imipramine for the treatment of depression suddenly presents with dry mouth and blurred vision. The adverse effects are due to blockade of which among the following receptors
    1. M1 muscarinic receptors
    2. M2 muscarinic receptors
    3. M3 muscarinic receptors
    4. 5-HT2 receptors

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16. Which among the following antihypertensives requires dosage reduction in slow acetylators?
    1. Hydralazine
    2. Labetalol
    3. Clonidine
    4. Esmolol

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17. Which of the following factors is associated with increased risk of digoxin toxicity
    1. Hyperkalemia
    2. Hypokalemia
    3. Hypermagnesemia
    4. Hypothyroidism

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18. Which of the following drugs when used in pregnancy leads to Phocomelia
    1. Thalidomide
    2. Misoprostol
    3. Doxylamine
    4. Ondansetron

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19. Which of the following antiarrhythmic drugs produces the adverse effect of corneal microdeposits?
    1. Lidocaine
    2. Esmolol
    3. Amiodarone
    4. Adenosine

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20. Fexofenadine is an active metabolite of
    1. Terbutaline
    2. Salbutamol
    3. Terfenadine
    4. Cyproheptadine

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