Download NTRUHS 2nd Year MBBS 2025 January Pharmacology Paper I MCQs Question Paper

Dr NTR UNIVERSITY OF HEALTH SCIENCES : VIJAYAWADA - 8

MBBS DEGREE EXAMINATION - JANUARY, 2025

SECOND M.B.B.S. EXAMINATION

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PHARMACOLOGY -PAPER-I (SET-C)

(Multiple Choice Questions)

Max Marks: 20

Time: 20 Minutes

Note: Answer all questions.

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1X2=20

SECTION-I (MCQs - 20 MARKS)

1. Down regulation of receptors can occur as a consequence of:
   1. Denervation
   2. Continuous use of antagonists
   3. Chronic use of CNS depressants

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   4. Continuous use of agonists
2. The following attribute of a drug tends to reduce its volume of distribution:
   1. High lipid solubility
   2. Low ionization at physiological pH values
   3. High plasma protein binding

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   4. High tissue binding
3. The following is an a2 adrenergic agonist used as eyedrops to lower intraocular pressure:
   1. Brinzolamide
   2. Bambuterol
   3. Brimonidine

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   4. Latanoprost
4. Transdermal drug delivery systems offer the following advantages except:
   1. They produce high peak plasma concentration of the drug
   2. They produce smooth and non-fluctuating plasma concentration of the drug
   3. They minimize inter individual variations in the achieved plasma drug concentration

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   4. They avoid hepatic first-pass metabolism of the drug
5. N-acetyl cysteine is beneficial in acute paracetamol poisoning because
   1. It reacts with paracetamol to form a nontoxic complex
   2. It inhibits generation of the toxic metabolite of paracetamol
   3. It is a free radical scavenger

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   4. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol
6. Select the drug which can improve urinary flow rate in benign prostatic hypertrophy without affecting prostate size
   1. Amphetamine
   2. Terazosin
   3. Finasteride

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   4. Goserelin
7. Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity
   1. Lignocaine
   2. Quinidine
   3. Verapamil

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   4. Amiodarone
8. Arginine vasopressin is preferred over desmopressin in the following condition
   1. Diabetes insipidus
   2. Bedwetting in children
   3. Bleeding esophageal varices

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   4. Bleeding in haemophilia
9. The calcium channel blocker used for prophylaxis of migraine but not for angina pectoris is
   1. Verapamil
   2. Diltiazem
   3. Flunarizine

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   4. Amlodipine
10. Dantrolene sodium reduces skeletal muscle tone by
    1. Reducing acetylcholine release from motor nerve endings
    2. Suppressing spinal polysynaptic reflexes
    3. Inhibiting the generation of muscle action potential

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    4. Reducing Ca2+ release from sarcoplasmic reticulum in the muscle fibre
11. Disease modifying antirheumatic drugs are indicated in rheumatoid arthritis
    1. In place of NSAIDs in patients who do not tolerate the latter
    2. Along with NSAIDs in patients with progressive disease
    3. Only when NSAIDs fail to afford symptomatic relief

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    4. In all patients irrespective of disease status/concurrent medication
12. Select the antihistaminic which modulates calcium channels and has prominent labyrinthine suppressant property
    1. Cyproheptadine
    2. Cinnarizine
    3. Clemastine

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    4. Cetirizine
13. Select the drug which is an 'inodilator' beneficial in refractory congestive heart failure
    1. Nicorandil
    2. Amiodarone
    3. Amrinone

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    4. Carvedilol
14. Which general anaesthetic selectively inhibits excitatory NMDA receptors
    1. Thiopentone
    2. Halothane
    3. Desflurane

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    4. Ketamine
15. Which of the following drug is a potassium channel opener
    1. Nicorandil
    2. Hydralazine
    3. Glibenclamide

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    4. Amiloride
16. The mechanism of action of barbiturates differs from that of benzodiazepines in that they
    1. Do not affect the GABA-benzodiazepine receptor-chloride channel complex
    2. Act as inverse agonists at the benzodiazepine receptor
    3. Increase the frequency of chloride channel opening without affecting its life time

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    4. Have both GABA-facilitatory as well as GABA-mimetic actions
17. Which of the following is a specific inhibitor of the enzyme alcohol dehydrogenase and is useful in the treatment of methanol poisoning
    1. Disulfiram
    2. Ethylene glycol
    3. Calcium leucovorin

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    4. Fomepizole
18. Which of the following is a non-sedative anxiolytic
    1. Chlorpromazine
    2. Buspirone
    3. Hydroxyzine

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    4. Alprazolam
19. In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine
    1. Mydriasis
    2. Marked respiratory depression
    3. Cyanosis

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    4. Fall in blood pressure
20. The antipsychotic drug most likely to cause ocular toxicity on long-term use is
    1. Thioridazine
    2. Haloperidol
    3. Flupenthixol

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    4. Pimozide

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