Download OU B.Pharma 2-1 Year 2013 2758 Pharmaceutical Organic Chemistry I Question Paper

Pharmaceutical Organic Chemistry - I

Time: 3 Hours Max. Marks: 70

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Note: Answer All questions. All questions carry equal marks.

1. (a) Discuss the following with suitable examples (4x3.5)
   1. Polarity and dipole moment
   2. Hybridization
   3. Atomic and molecular orbitals
   4. Hydrogen bonding

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   OR (b)
   1. Explain the energy diagrams of reactants and products during the course of reaction. (7)
   2. Write a note on the following: (7)
      1. Resonance
      2. Inductive and mesomeric effect

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2. (a)
   1. Explain Markovnikov's and Anti-Markovnikov's addition with examples. (7)
   2. Explain the mechanism involved in the addition of HBr to 2-Butene according to Markovnikov's and anti-Markovnikov's addition. (7)
   OR (b)
   1. Write any four methods of preparation of alkenes. (4)
   2. Discuss Bayer's strain theory. (3)
   3. Discuss various conformations of cyclohexane and n-Butane giving their stability. (7)

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3. (a)
   1. Write any four methods to prepare n-propyl bromide. (4)
   2. Discuss in detail the mechanism and stereochemistry involved in SN1 and SN2 reactions. (10)
   OR (b)
   1. Explain the mechanism involved in dehydration of alcohols. (7)
   2. How do you prepare ethers by Williamson's synthesis? (3)

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   3. List out the differences between Nucleophilic substitution Vs. Elimination. (4)
4. (a)
   1. Discuss any four nucleophilic addition reactions of carbonyl compounds with mechanisms. (7)
   2. How do you synthesize Schiff bases? (3)
   3. Write any three methods of preparation of aldehydes. (4)

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   OR (b)
   1. Write in detail the acidity of carboxylic acids. (3)
   2. Write any three methods to synthesize carboxylic acids. (3)
   3. Discuss the reactivity and synthetic applications of Diethyl malonate and Ethylacetoacetate. (8)
5. (a)
   1. Discuss basicity and important reactions of amines. (6)

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   2. Give the synthetic applications of aryl diazonium salts. (4)
   3. Explain Hinsberg's method of separation of amines. (4)
   OR (b)
   1. Write a note on Sandmeyer's reaction. (3)
   2. Write any three methods to prepare nitro alkanes. (5)
   3. Write any four important reactions of amines. (6)

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