Download OU B.Pharma 2-1 Year 2010 4409 Pharmaceutical Analysis I (Chemical Analysis) Question Paper

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FACULTY OF PHARMACY

B. Pharmacy II Year I Sem. (Main) Examination, November/December 2010

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PHARMACEUTICAL ANALYSIS — I (Chemical Analysis)

Time : 3 Hours] [Max. Marks: 70

Note : Answer all questions. All questions carry equal marks.

1. a)
   1. Define and explain.
      1. Relative Error
      2. Indeterminate Error

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      3. Gross Error
   2. Describe the methods of expressing concentration.
   3. Calculate the equivalent weight of the following :
      1. K₂Cr₂O₇
      2. NaOH

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      3. H₂SO₄
      4. KMnO₄
   OR b)
   1. What are Primary standard and Secondary standard substances ? Mention few examples of each.
   2. The following results were obtained in the replicate analysis of a blood sample for its lead content 0.754, 0.756, 0.752, 0.751 and 0.760 PPM pb. Calculate the Mean, Standard deviation, Range and Median.

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2. a)
   1. What is common Ion Effect ? Discuss its applications in pharmaceutical analysis.
   2. Discuss the modern concepts of acidity and basicity. Give some examples.
   OR b)
   1. How much water is to be added to a 150 ml of solution of 0.25N HCl to make it 0.1 N solution ?
   2. Write a note on neutralization indicator.

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   3. Derive an equation to calculate the pH value of an aqueous solution of a salt of weak acid and strong base.
3. a)
   1. Write a note on
      1. Coagulation
      2. Digestion

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   2. Explain the theories involved for determination of chloride in
      1. Mohr's method
      2. Volhard's method
      3. Fajan's method
   OR b)
   1. What is oxidation-reduction potential and write how it is determined the redox system ?

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   2. What are Redox Indicators ? What is the chemical process causes them to change color ?
   3. Calculate the normality of the following 2M K₂Cr₂O₇.
4. a)
   1. How do you prepare and standardise the following solutions
      1. 0.01M EDTA
      2. 0.1N HClO₄

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   2. How do you estimate the hardness of water using complexometry ?
   OR b)
   1. What is the difference between Iodometry and Iodimetry ? Explain with the help of one suitable examples. Write the principle and procedure of Iodometric assay of any official compound.
   2. Write a note on different solvents used in Non-aqueous titration.

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5. a)
   1. How much is mass of NaOH required to convert 7.3 g of HCl to NaCl ?
   2. Calculate the percentage composition of elements in Na₂S₂O₃ (Atomic weight Na, S, O are 23, 32, 16 respectively )
   3. Define Stoichiometry, mole and percentage yield.
   OR b)
   1. How will you balance the following equation by applying Ion-electron method ?
      KMnO₄ + FeSO₄ + H₂SO₄ -> Fe₂(SO₄)₃ + K₂SO₄ + MnSO₄ + H₂O

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   2. What is Avagadro's number ? Explain how the moles of elements are measured.
   3. Calculate the normality of 10 milli moles of Na₂S₂O₃ in 200 ml of solution.

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