Download OU B.Pharma 2-1 Year 2010 7007 Pharmaceutical Organic Chemistry I Question Paper

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Code No. 7007

FACULTY OF TECHNOLOGY

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B.Pharmacy II Year I Semester (Suppl.) Examination, June 2010

PHARMACEUTICAL ORGANIC CHEMISTRY — I

Time: 3 Hours] [Max. Marks: 70

Note : Answer all questions.

All questions carry equal marks.

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1. a) Explain the following with suitable examples :
   1. Inductive effect
   2. Dipolemoment
   3. Tautomerism
   4. Resonance. (3.5x4=14)
   OR b)
   1. Predict the hybridization, geometry and bond angles in the following :
      1. CH;—Ca-N

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      2. CH,=N—CHj3;
      3. CH3;CHO
   2. What is activation energy ? Explain the energy diagram of reactants and products during a course of reaction with example. 8

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2. a)
   1. Write any two methods of preparation of alkanes. 6
   2. Discuss the important free radical reactions of alkanes. 8
   OR b)
   1. Explain Markovnikov's addition and peroxide effect with suitable examples. 7
   2. What type of compounds exhibit geometrical isomerism ? Explain E-Z system of nomenclature. 7

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3. a)
   1. Explain the mechanism and stereochemistry of SN¹ reactions. 10
   2. Describe any four methods of preparation of alkyl halides. 10
   OR b)
   1. Discuss the mechanism and stereochemistry of elimination reactions. 10
   2. Explain Ziesel's method. 10

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4. a)
   1. Describe the preparation of benzoic acid from benzaldehyde.
   2. Describe the general methods of preparation of carboxylic acids.
   3. Write a note on reactivity and synthetic uses of ethylacetoacetate.
   OR b)
   1. Describe the nucleophilic addition reactions of aldehydes and ketones.
   2. Explain the mechanism involved in the preparation of schiff bases.

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5. a)
   1. Write about the reactions of primary, secondary and tertiary amines with HNO₂.
   2. Write a note on basicity of amines.
   3. Describe the Hinsberg's method separation of amines.
   OR b)
   1. Give the preparation and synthetic applications of aryl diazonium salts.

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   2. Write any two general methods of preparation Nitroalkanes.

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