Download OU B.Pharma 2-1 Year 2017 1066 Pharmaceutical Oranic Chemistry I Question Paper

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Code No. 1066

FACULTY

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B. Pharmacy 2/4 I - Semester (Supplementary) Examination, November 2017

Subject : Pharmaceutical Organic Chemistry I

Time : 3 hrs Max. Marks : 70

Note: Answer all questions. All questions carry equal marks.

1. 1. Explain the following terms with suitable examples:
      1. Inductive effect

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      2. Mesomeric effect
      3. Resonance
      (2+3+3)
   2. How do you differentiate between enantiomers and diastereomers? Explain with suitable examples. (6)

   OR

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   1. Discuss the following with suitable examples:
      1. Polarity
      2. Solubility
      3. Inter molecular forces
      (2+2+2)
   2. Explain SP³, SP² and SP hybridization. (8)

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2. 1. Discuss the importance of Bayer’s strain theory. (7)
   2. Write general methods of preparation of alkynes. (7)

   OR

   1. Explain the reactions of alkenes. (7)

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   2. Discuss the free radical mechanism for the chlorination of methane. (7)
3. 1. Explain E¹ and E² elimination reactions with mechanism. (5)
   2. Give any three methods to synthesize alkyl-halides. (9)

   OR

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   1. Discuss the Williamson’s synthesis of ethers. (7)
   2. Explain Walden inversion and Ziesel's method. (7)
4. 1. Write synthetic applications of Diethyl Malonate and Ethyl aceto acetate. (7)
   2. Discuss any three nucleophilic addition reactions of carbonyl compounds with mechanism. (7)

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   OR

   1. Write any three methods of preparation of aldehydes and ketones. (9)
   2. Give the reasons for following statements:
      1. Bromo acetic acid is weaker than chloro acetic acid. (2+1/2)
      2. Formic acid is stronger than acetic acid. (2+1/2)

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5. 1. How to separate mixtures of amines by different methods? (10)
   2. Write any two methods to prepare Nitro alkanes. (4)

   OR

   1. Give the synthetic applications of aryl diazonium salts. (8)

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   2. Write any three important reactions of amines. (6)