Download OU B.Pharma 2-1 Year 2017 4213 Pharmaceutical Oranic Chemistry I Question Paper

FirstRanker.com

Code No. 4213

B. Pharmacy 2/4 I - Semester (Suppl.) Examination, April 2017

--- Content provided by‍ FirstRanker.com ---

Subject: Pharmaceutical Organic Chemistry - I

Time: 3 Hrs

Max. Marks: 70

Note: Answer all questions. All questions carry equal marks.

1. a) Discuss the effect of intramolecular and intermolecular forces. (8)
   

   --- Content provided by⁠ FirstRanker.com ---

   b) Explain the following terms: (3x2=6)
      i) Inductive effect
      ii) Resonance effect.

   OR

   c) What is isomerism? Write about structural isomerism. (7)
   d) Add a note on activation energy. (5)
   

   --- Content provided by​ FirstRanker.com ---

   e) Define the terms with examples: (3x2=6)
      i) Bond angle
      ii) Heterolysis.
2. a) Write the reaction and mechanism of antimarkovnikov's addition. (7)
   b) Give the structural formulas of the following: (3x2=6)
   

   --- Content provided by​ FirstRanker.com ---

      i) 4 Ethyl 2,4 dimethyl heptane
      ii) 1,2 Dibromo 2 methyl propane
      iii) 3 Ethyl 2 methyl pentane.

   OR

   c) Write any two methods for synthesis of alkenes. (7)
   d) Explain the stability of cycloalkanes by different theories. (5)
   

   --- Content provided by​ FirstRanker.com ---

   e) Write any two chemical reactions of alkanes. (6)
3. a) Give the structural formulas for the following: (3x2=6)
      i) 2 Bromo ethanol
      ii) Tert butyl isobutyl ether
      iii) 2 Fluoro 3 pentanol
   

   --- Content provided by​ FirstRanker.com ---

      iv) n Butyl ethyl ether
   b) Write the mechanism of dehydration of alcohols. (7)
   c) Add a note on Walden inversion. (5)

   OR

   d) Give the reasons for following statements: (6)
      i) Alcohols have higher boiling points than alkanes
   

   --- Content provided by FirstRanker.com ---

      ii) Lower alcohols are soluble in water
   e) How will you distinguish between primary, secondary and tertiary alcohols with examples? (7)
   f) Discuss the mechanism for SN reactions. (5)
4. a) Give the mechanisms for the following: (3x2=6)
      i) Aldol condensation
   

   --- Content provided by‌ FirstRanker.com ---

      ii) Haloform reaction
      iii) Wittig reaction

   OR

   b) Write any four methods for preparation of carbonyl compounds. (14)
5. c) Write the general methods of preparation of carboxylic acids. (7)
   d) Discuss reactivity and applications of acetoacetic ester. (7)

--- Content provided by FirstRanker.com ---

6. a) How will you separate a mixture of amines with different methods. (7)
   b) Write about the reactions of amines. (7)

   OR

   c) Give the synthetic applications of aryl diazonium salt. (7)
   d) Write the nomenclature and acidity of nitro alkanes. (4)
   e) Give a note on diazotization and Sandmeyer reaction. (3)

--- Content provided by⁠ FirstRanker.com ---

FirstRanker.com