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B.Pharmacy II Year I Sem (Supplementary) Examination, April/May 2011
PHARMACEUTICAL CHEMISTRY - I
Time : 3 Hours] [Max. Marks : 70
Answer all questions.
All questions carry equal marks.
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- (a) (i) Explain the determination of configuration Isomers by physical and chemical methods with suitable examples.
(ii) Give a brief note on optical isomerism.
Or
(b) Explain the following terms with suitable examples. (4x3.5=14)
(i) Enantiomers (ii) Dipole movement--- Content provided by FirstRanker.com ---
(iii) Metamerism (iv) Resonance - (a) (i) Write any three methods of preparation of cyclo alkanes.
(ii) Explain the terms with suitable examples. (3x3=9)
(A) Pyrolysis (B) Markonikov's addition
(C) Peroxide effect.--- Content provided by FirstRanker.com ---
Or
(b) (i) How will you synthesize the following: (3x2=6)
(A) Ethane from acetic acid
(B) n-butane from ethyl bromide
(C) Benzene from n-Hexane--- Content provided by FirstRanker.com ---
(ii) Explain the mechanism of nitration of alkanes.
(iii) Write a note on Baeyer strain theory. - (a) (i) Discuss the mechanism of E1 reaction of alkyl halides.
(ii) Write a note on Saytzeff rule.
(iii) Give the reasons for following statements : 3x2=6--- Content provided by FirstRanker.com ---
(A) Allyl chloride is less reactive than ethyl chloride.
(B) Lower alcohols are soluble in water.
(C) Methyl alcohol boils at lower temperature than water.
Or
(b) (i) Write any four methods to prepare alcohols. (6)--- Content provided by FirstRanker.com ---
(ii) Explain Zeisels method.
(iii) Give the mechanism for Williamson's synthesis to synthesize ethers. - (a) (i) Explain the acidity of carboxylic acid with examples.
(ii) How will you synthesize the following compounds from the indicated materials. (4x2=8)
(A) Propanone from 2-propanol--- Content provided by FirstRanker.com ---
(B) Acetaldehyde from formic acid
(C) Propionic acid from ethene
(D) Ethyl acetate from acetic anhydride.
Or
(b) (i) Write the reactivity and synthetic uses of ethyl acetoacetate.--- Content provided by FirstRanker.com ---
(ii) Give the reasons for following statements. (3x3=9)
(A) Esters are less reactive than acid halides.
(B) Acetic acid is stronger than propionic acid.
(C) Trichloroacetic acid is stronger than formic acid. - (a) (i) Write any three methods to synthesize nitroalkanes.
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(ii) How do you differentiate between primary, secondary and tertiary amines with chemical reactions.
Or
(b) (i) Write the preparation and synthetic applications of benzene diazonium chloride. (5)
(ii) Give the reasons for following statements. (3x3=9)
(A) Methyl amine is a stronger base than ammonia.--- Content provided by FirstRanker.com ---
(B) Dimethylamine has a higher boiling point than trimethylamine.
(C) Secondary amines are more basic than primary amines.
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