Download OU B.Pharma 3-1 Year 2013 2768 Medicinal Chemistry I Question Paper

Medicinal Chemistry

Max. Marks: 70

Note: Answer All questions. All questions carry equal marks.

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1. (a) Explain in detail the phase-I reactions of drug metabolism with examples.
   (b) Explain the role of prodrugs in drug design.
   OR
   (c) Explain different physicochemical properties which influence biological activity.
   (d) Write the importance of steric features of drugs.

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2. (a) What are adrenomimetics? Write SAR and uses of adrenergic drugs.
   (b) Classify parasympathomimetics with examples.
   OR
   (c) Give the synthesis of (i) Atenolol (ii) Salbutamol.
   (d) Write the structures and uses of acetyl choline esterase inhibitors.

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3. (a) Give the classification of Antihypertensive drugs with structures and write the synthesis of captopril and clonidine.
   OR
   (b) Classify antiarrhythmic drugs with one suitable example for each class.
   (c) Write notes on antihyperlipidemic agents.
   (d) Define and classify diuretics with examples.

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4. (a) Write about hypoglycemic drugs.
   OR
   (b) Write notes on Immunostimulants.
   (c) Give the synthesis of (i) Amiloride (ii) Gliclazide
   (d) Write notes on proton pump inhibitors.

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5. (a) Explain in detail about anti-coagulation.
   OR
   (b) Write the synthesis, M.O.A. of following drugs:
   (i) Cetirizine (ii) Ranitidine
   (c) Explain the SAR of H1 antagonists.

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