Download OU B.Pharma 3-1 Year 2014 7217 S Medicinal Chemistry I Question Paper

Note: Answer all questions. All questions carry equal marks.

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1. 1. Explain protein binding in relation to drug action.

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   2. Explain the physicochemical properties in relation to biological activity.

   OR

   1. Describe the role of soft drug approach in drug design.
   2. Discuss in detail phase-II reactions involved in drug metabolism.

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2. 1. What are cholinergic agents? Write the structural features necessary for a molecules to show cholinergic activity.
   2. Write the synthesis and therapeutic use of:
      (A) Salbutamol (B) Prazocin

   OR

   1. Classify Adrenergic blocking agents by giving one example for each category with structures.

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   2. Write the synthesis, mechanism of action and uses of following drugs:
      (A) Atenalol (B) Mecamylamine HCI
3. 1. Give the classification of anti hypertensive drugs with examples.
   2. Write the synthesis and uses of:
      

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      (A) Captopril (B) Clonidine

   OR

   1. Classify anti-hyper lipidemic agents with suitable examples.
   2. Write a note on cardiac glycosides and mechanism of action.

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4. 1. Write the synthesis and mechanism of action of nifedipine.
   2. Write the general synthesis of sulfonyl ureas. Write their mechanism of action and SAR.

   Write a note on anti thyroid drugs:

   OR

   1. What are diuretics? Classify them with suitable examples.

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   2. Write the synthesis, mechanism of action and uses of:
      (A) Furesomide (B) Acetazolamide
5. 1. Write a note on proton pump inhibitors.
   2. Write the synthesis, mechanism of action and uses of:
      

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      (A) Chlorpheniramine (B) Omeprazole

   OR

   1. Classify H₁ anti histaminic drugs with one example for each class with structures.
   2. Write a short note on anti coagulant and mention the synthesis and mechanism of action of warfarin.

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