Download OU B.Pharma 3-1 Year 2014 8048 Medicinal Chemistry Question Paper

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Code No. 8048

FACULTY OF PHARMACY

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B.Pharmacy 3/4 |- Semester (Main) Examination, October/November 2014

Subject: Medicinal Chemistry - |

Time: 3 Hours Max. Marks: 70

Note: Answer all questions. All questions carry equal marks.

1. Define and give its significance of following: (4 x3)

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   1. Ionization
   2. Surface activity
   3. Hydrogen bonding
   4. lipophilicity

   Give the applications of Bio-isosterism. (2)

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   OR

   Discuss in detail conjugation reactions involved in drug metabolism. (7)

2. Write the importance of steric features of drugs. (7)

   Identity the following drug and give its structure and name. (8)

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   1. Nitrite with vasodilator action
   2. Iomidazole derivatives with anti-hypertensive action
   3. Dihydropyridine derivative with anti arrhythmic action
   4. Steroidal compound with positive lonotropic action

   Write a note on HmG — CoA reductase institutions. (6)

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   OR

   Give the structure, synthesis MOA and uses of following: (3x4)

   1. Ticlopidine
   2. Captopril
   3. Nefidipine

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3. How do you differentiate between cardienolides and Bufadinolides? (2)

   Explain the S.A.R. of B-Adrenergic blocking agents. (6)

   Outline the synthesis mechanism of action (MoA) and uses of salbutamol and mecamylamine HCI. (2x4)

   OR

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   Add a note on ganglionic blocking agents. (6)

   Give the structure, MoA and synthesis of isoproferenol and meprobamata. (2x4)

4. Give the structure, synthesis and adverse effects of (4x3)

   1. Amrinone

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   2. Hydro chlorthiazide
   3. Furosemide
   4. Glyclazide

   Add a note on Anti-thyroidal agent. (2)

   OR

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   Discuss in detail structural activity relationship for Tolbutamide ring. (5)

   Give the structure, synthesis and MoA of following: (3x3)

   1. Acetazolamide
   2. Prophylthiouracil
   3. Amiloride

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5. Explain in detail S.A.R of Hy — Anti histaminics. (10)

   Add a note on proton pump inhibitors. (4)

   OR

   Give the structure synthesis and MoA of following: (3x4)

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   1. Ranitidine
   2. Omeprazole
   3. Diphenhydramine

   List out the coagulation factors. (2)

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