Download OU B.Pharma 3-1 Year 2015 8048 S Medicinal Chemistry I Question Paper

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Pharmacy, Code No. 8048 / S

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FACULTY OF PHARMACY

B. Pharmacy 3/4 |- Semester (Supplementary) Examination, April 2015

Subject : Medicinal Chemistry - |

Time : 3 hours Max. Marks : 70

Note: Answer all questions. All questions carry equal marks.

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1. a) Explain physicochemical properties which influence biological activity. 7
   b) Write the importance of bio-isosterism in drug design. 7
   OR
   b) Discuss about prodrug approach in drug design. 7
   d) Give a note on drug distribution and protein binding. 3+4

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2. a) Explain S.A.R. of Acetyl cholinesterase inhibitors. 6
   b) Give the structure, synthesis and MoA of following : 4+4
   A) Dicyclomine HCI B) Carbachol
   OR
   c) Write a note on skeletal muscle relaxants. 6
   

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   d) Discuss S.A.R. of Adrenomimetics. 8
3. a) Classify anti arrhythmic drugs with suitable example and explain S.A.R. in detail. 2+6
   b) What are antihypertensives with examples? Give the synthesis of captopril and clonidine. 2+2+2
   OR
   c) Write a note on Anti-hyperlipidemic agents. 5
   

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   d) Write a note on Cardiac glycosides and their mechanism of action. 5
   e) Give the structure and synthesis of verapamil and dipyridamole. 2+2
4. a) Write a note on positive Inotropic agents. 5
   b) Give the structure, synthesis and MoA of following : 3+3+3
   1) Amiloride 2) Tolbutamide 3) Propylthiouracil
   

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   OR
   c) What are diuretics and give the classification with suitable examples. 1+2
   d) Add a note on oral hypoglycemic agents. 5
   e) Write a short note on Immunomodulator drugs. 6
5. a) Write the structural activity relationship and MoA of proton pump inhibitors. 8
   

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   b) Give the synthesis and MoA of Ranitidine and chlorpheniramine. 3+3
   OR
   c) Discuss about coagulants and anti-coagulants. 2+4
   d) Give the structure, synthesis and MoA of Diphenhydramine and Omeprazole. 4+4

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