Download OU B.Pharma 3-1 Year 2016 4048 Medicinal Chemistry I Question Paper

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Code No. 4048

FACULTY

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B. Pharmacy 3/4 | — Semester (Main) Examination, October 2016

Subject: Medicinal chemistry - |

Time: 3 Hrs Max.Marks: 70

Note: Answer all questions. All questions carry equal marks.

1. 1. Write about bioisosterism and steric factors of drugs. (7)

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   2. Explain the concept of pro and soft drug approach. (7)

   OR

   1. Explain about the following terms with examples:
      1. Lipophilicity
      2. Partition coefficient
      3. Solubility

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      4. Ionization (4+3+4+3)
2. 1. Explain S.A.R of adrenergic blocking agents. (8)
   2. Write the synthesis and mechanism of action of mecamylamine HCI and Meprobamate. (6)

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   OR

   1. Give the structure, synthesis and mechanism of action of following: (7)
      1. Isoproterenol
      2. Salbutamol
   2. Add a note on neuromuscular blocking agents: (7)

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3. 1. Classify antihypertensive drugs with examples and SAR of ACE inhibitors. (9)
   2. Explain mechanism of action and uses of cardiac glycosides. (5)

   OR

   1. Define and classify antihyperlipidemic drugs with examples and SAR of statins. (7)

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   2. Give the synthesis of following:
      1. Diltiazem (3)
      2. Captopril (4)
4. 1. Define and classify diuretics with examples. Write the mechanism of action and therapeutic uses of carbonic anhydrase inhibitors. (7)

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   2. Discuss the mechanism of action and limitations of oral hypoglycemic agents. (7)

   OR

   1. Write a note on positive ionotropic agents. (7)
   2. Give a note on immuno suppressants and immuno stimulants. (7)

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5. 1. Classify anti histaminic agents. Discuss in detail mechanism of action of H1 antagonists. (14)

   OR

   1. Give a note on proton pump inhibitors. (7)
   2. Discuss in detail about coagulants and anticoagulants. (7)

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