Download OU B.Pharma 3-1 Year 2016 6048 Medicinal Chemistry I Question Paper

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Code No. 6048

FACULTY

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B. Pharmacy 3/4 I - Semester (Suppl.) Examination, April 2016

Subject: Medicinal Chemistry - I

Time: 3 Hrs Max.Marks: 70

Note: Answer All questions. All questions carry equal marks.

1. 1. Explain with examples the importance of partition coefficient in relation to biological activity of drugs. (7)

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   2. What are prodrugs? How are they obtained? Mention their merits and demerits. (7)

   OR

   1. Discuss with suitable examples the influence of steric features of drugs on biological activity. (7)
   2. Discuss with examples the importance and significance of Phase II reactions. (7)

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2. 1. Classify anionic blocking agents with examples, write the mode of action, SAR and outline the synthesis of Mecamylamine. (2+3+5+4)

   OR

   1. Write short notes on:
   1. Adrenergic blocking agents (7)
   2. Cholinergic blocking agents (7)

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3. 1. What are anti-arrhythmic agents? Classify them with examples, discuss the mode of action and SAR. (2+3+3+3)
   2. Write the synthesis and specific uses of Nifedipine. (3)

   OR

   1. Give an account of:

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   1. Cardiotonic drugs (7)
   2. Vasodilators (7)
4. 1. Outline the synthesis and uses of (a) Amiloride (b) Tolbutamide (c) Propylthiouracil (5+5+4)

   OR

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   1. Write briefly on (a) Thyroid agents (b) Immunosuppressant. (7+7)
5. 1. Classify H2 receptor antagonists with examples, write the mode of action and SAR. Outline the synthesis and uses of Ranitidine. (3+2+3+6)

   OR

   1. Outline the synthesis and uses of (a) Omeprazole (b) Cetrizine (c) Diphenhydramine. Write a note on anticoagulants. (6+5+3)

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