Download OU B.Pharma 3-1 Year 2018 13043NON CBCS Medicinal Chemistry I Question Paper

FirstRanker.com

B. Pharmacy III/IV II-Semester (Non CBCS) (Backlog) Examination, November 2018

Subject: Medicinal Chemistry I

--- Content provided by‌ FirstRanker.com ---

Time: 3 Hrs Max. Marks: 70

Note: Answer all questions. All questions carry equal marks.

1. 1. Write the importance of steric features of drugs
   2. Explain the concept of pro and soft drug approach.

   OR

   --- Content provided by FirstRanker.com ---

   1. Discuss in detail phase I reactions involved in the drug metabolism.
   2. Explain about (i) lipophilicity (ii) Solubility with examples
2. 1. Write the pharmacological actions of Adrenaline and discuss the SAR of adrenomimetics.
   2. Give the structure and synthesis of following:
      1. Salbutamol

      --- Content provided by​ FirstRanker.com ---

      2. Isoproterenol

   OR

   1. Write notes on following:
      1. Cholinergic blocking agents
      2. Skeletal muscle relaxants

      --- Content provided by FirstRanker.com ---

3. 1. Define anti-hypertensive and give the classification with examples.
   2. Write the SAR of ACE inhibitors.
   3. Give the structure and synthesis of clofibrate.

   --- Content provided by FirstRanker.com ---

   OR

   1. Add a note on Antiplatelet drugs
   2. Discuss about cardiotonic agents
4. 1. Give the classification of oral hypoglycemic agents with examples.

   --- Content provided by​ FirstRanker.com ---

   2. Add a note on positive Inotropic agents
   3. Give the structure, uses and synthesis of Tolbutamide.

   OR

   1. Define and classify diuretics with examples. Write the MOA and SAR of carbonic anhydrase inhibitors.
   2. Add a note on Immuno suppressants.

   --- Content provided by FirstRanker.com ---

5. 1. Define and classify Anti-histaminic agents with examples.
   2. Give the SAR of any two classes of H1 Anti-histaminic.
   3. List the coagulation factors.

   OR

   --- Content provided by⁠ FirstRanker.com ---

   1. Write the structure, synthesis, MOA and uses of following:
      1. Chlorpheniramine
      2. Ranitidine
      3. Omeprazole
      4. Warfarin

   --- Content provided by‌ FirstRanker.com ---

FirstRanker.com