Download OU B.Pharma 3-1 Year 2019 6155NON CBCS Medicinal Chemistry I Question Paper

Download OU (Osmania University) B.Pharma 3-1 (3rd Year 1st Sem) (Bachelor of Pharmacy) 2019 6155NON CBCS Medicinal Chemistry I Previous Question Paper

OU - 1701 OU - 1701
Code No.6155/Non-CBCS
FACULTY OF PHARMACY
B. Pharmacy 3/4 I-Semester (Non-CBCS) (Backlog) Examination,
December 2019
Subject: MEDICINAL CHEMISTRY - I
Time: 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1. (a) Discuss in detail the importance of steric features of drugs. 7
(b) Explain the role of cytochrome 450 enzyme in drug Metabolism. 7
OR
(c) Explain how the following physicochemical properties influence the biological action
of a drug molecule. 14
(i) Partition coefficient (2) Chelation (3) Hydrogen bonding (4) Redox
potentials. (4+4+3+3)
2. (a) Explain the SAR of Adrenergic blocking agents. 8
(b) Give the synthesis, uses and MOA of Salbutanel and Dicyclomine Hcl. 3+3
OR
(c) Add a note on Ganglionic blocking agents. 8
(d) Give the synthesis and MOA of Carpochol and Isoproteronol. 3+3
3. (a) What are antihypertensive agents. Classify them with examples. Discuss the SAR
of ACE inhibitors 1+2+5
(b) Give the synthesis and uses of clonidine and captopril. 3+3
OR
(c) Add a note on antiplatelet drugs. 6
(d) Give the synthesis, MOA and uses of clofibrate and verapanil. 4+4
4. (a) Explain the SAR of any two types of Diuretics. 8
(b) Add a note on Immuno suppressants. 6
OR
(c) Discuss the chemistry of Antithyorid agents. 6
(d) Give a note on Hypoglycemic agents and write the synthesis of Tolbutamide. 6+2
5. (a) Classify antitristamines with examples. Explain the SAR of H
1
antitristamines. 2+7
(b) Write the synthesis of citrizine and Ranitidine. 3+2
OR
(c) Add a note on proton pump intribitors. 6
(d) Give the synthesis and MOA of Omeprozole and Diphetrydramine. 8
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Pharmacy

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