Download OU B.Pharma 3-1 Year 2019 6155NON CBCS Medicinal Chemistry I Question Paper

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Code No: 06155/Non-CBCS

FACULTY OF PHARMACY

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B. Pharmacy 3/4 I-Semester (Non-CBCS) (Backlog) Examination, December 2019

Subject: MEDICINAL CHEMISTRY -1

Time: 3 Hours Max. Marks: 70

Note: Answer all questions. All questions carry equal marks.

1. (a) Discuss in detail the importance of steric features of drugs.
   

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   (b) Explain the role of cytochrome 450 enzyme in drug Metabolism.
   OR
   (c) Explain how the following physicochemical properties influence the biological action of a drug molecule.
   1. Partition coefficient
   2. Chelation
   3. Hydrogen bonding

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   4. Redox potentials. (4+4+3+3)
2. (a) Explain the SAR of Adrenergic blocking agents. 8
   (b) Give the synthesis, uses and MOA of Salbutanel and Dicyclomine Hcl. 3+3
   OR
   

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   (c) Add a note on Ganglionic blocking agents. 8
   (d) Give the synthesis and MOA of Carpochol and Isoproteronol. 3+3
3. (a) What are antihypertensive agents. Classify them with examples. Discuss the SAR of ACE inhibitors 1+2+5
   (b) Give the synthesis and uses of clonidine and captopril. 3+3
   OR
   

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   (c) Add a note on antiplatelet drugs: 6
   (d) Give the synthesis, MOA and uses of clofibrate and verapanil. 4+4
4. (a) Explain the SAR of any two types of Diuretics. 8
   (b) Add a note on Immuno suppressants. 6
   OR
   

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   (c) Discuss the chemistry of Antithyroid agents. 6
   (d) Give a note on Hypoglycemic agents and write the synthesis of Tolbutamide. 6+2
5. (a) Classify antihistamines with examples. Explain the SAR of H1 antihistamines. 2+7
   (b) Write the synthesis of citrizine and Ranitidine. 3+2
   OR
   

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   (c) Add a note on proton pump inhibitors. 6
   (d) Give the synthesis and MOA of Omeprozole and Diphenhydramine. 8

Pharmacy

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