lOMoARcPSD|55903010
Madhya Pradesh Medical Science University, Jabalpur
MBBS Second Professional Examination June-2023
Subject- Pharmacology
Paper- II (new scheme)
Maximum Marks :100
Instructions:
a)
b)
Draw diagrams wherever necessary
c)
Answers of Questions and Sub-questions must be written strictly according to serial order of question paper.
MCQ has to be answered in theory answer book
e)
Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
counted in marks and action will be taken according to UFM rules of university.
g)
Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
10 x 1 = 10
1. Which of the following has the highest potential to cause metabolic syndrome?
(a) Clozapine
(b) Ziprasidone
(d) Aripiprazole
2. Which of the following drugs is effective in both Grand Mal and Petit Mal Epilepsy?
(a) Phenobarbitone
(b) Phenytoin
(d) Sodium Valproate
3. Drug which is NOT used in a patient of severe complicated Falciparum malaria:
(a) Chloroquine
(b) Quinine
(d) Artemether
4. Which insulin analogue can be administered intravenously?
(a) Insulin Glargine
(b) Insulin Lispro
(d) Insulin Detemir
5. Antipyretic Analgesic devoid of significant Anti-inflammatory effect is:
(a) Paracetamol
(b) Ketoprofen
(d) Aspirin
6. Drug of choice for neutropenia due to cancer chemotherapy is:
(a) IL-11
(b) Erythropoietin
(d) Vitamin-B12
7. ADR caused by bisphosphonates:
(a) Hepatotoxicity
(b) Esophageal Ulcers
(d) Osteoporosis
8. Which local anesthetic agent is associated with a higher risk of methemoglobinemia?
(a) Bupivacaine
(b) Prilocaine
(d) Procaine
9. Which class of antibiotics exhibits concentration-dependent killing and is characterized by a post-antibiotic
effect?
(a) Aminoglycosides
(c) Tetracyclines
(d) Macrolides
10. Which drug is a somatostatin analog used for the treatment of acromegaly and neuroendocrine tumors?
(a) Levothyroxine
(c) Octreotide
(d) Insulin lispro
lOMoARcPSD|55903010
Q2. Long Answer Questions
a. A 19-year-old man is brought to the OPD by his mother. He has been kicked out of the hostel for his "bizarre"
behavior. He has accused several fellow students and professors of spying on him for the CIA. He stopped
attending his classes and spends all of his time watching TV because the announcers are sending him secret
messages on how to save the world. He has stopped bathing and will only change his clothes once a week. His
psychosis secondary to schizophrenia, admit him to the psychiatric unit of the hospital, and start him on
haloperidol. (6+6+8=20)
1. What is the pharmacological basis of the use of Haloperidol in this condition?
2. What are the advantages of Atypical Antipsychotics over the Typical Antipsychotics?
ADRs.
b. A 58-year-old male weighing 55 kg presented with complaints of cough with expectoration, fever, and night
sweats since the last 4 weeks. He started experiencing shortness of breath since the last 4 days. X-ray chest
revealed a patchy area of consolidation. Sputum smear was positive for Acid Fast Bacilli. There is no previous
Tuberculosis based on NTEP guidelines. (4+10+6=20)
1. What is the Treatment Regime for Drug Susceptible Tuberculosis as per current NTEP Guidelines?
2. What is the basis of the use of these drugs in this regime? Enumerate the important ADRs of these drugs.
3. What do you mean by Drug Resistant Tuberculosis? Enumerate second-line Anti-TB Drugs.
6 x 05 = 30
a. Explain why abrupt cessation of Glucocorticoids after prolonged therapy is not advised? Enumerate the long-
term ADRs of Corticosteroids.
b. Why are SSRIs preferred in patients of Depression over other drugs?
d. Describe the management of Diabetic Ketoacidosis.
e. Write regimes used for Emergency Contraception explaining their mechanism of action.
f. Enumerate drugs used and explain their mechanism for action in the prophylaxis of migraine.
Q4. Short Answer Questions
a. Why Levodopa is not used in drug-induced parkinsonism?
b. Why Morphine is contraindicated in Head injury patients?
c. Why Oxytocin and not Ergometrine is used in Induction of Labour?
d. Write two drugs effective in the treatment of Methicillin-resistant Staphylococcal infections.
f. Why Adrenaline is combined with Lidocaine?
g. Write the Preferred first-line ART regimen based on the National Programme.
h. Drugs used in Chronic Gout.
i. Write the Absolute Contraindications of Hormonal Oral Combined Contraceptive pills.
Madhya Pradesh Medical Science University, Jabalpur
MBBS Second Professional Examination June-2023
Subject- Pharmacology
Paper- II (new scheme)
--- Content provided by FirstRanker.com ---
Time: 3:00 HoursMaximum Marks :100
Instructions:
a)
--- Content provided by FirstRanker.com ---
All questions are compulsoryb)
Draw diagrams wherever necessary
c)
Answers of Questions and Sub-questions must be written strictly according to serial order of question paper.
--- Content provided by FirstRanker.com ---
d)MCQ has to be answered in theory answer book
e)
Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
--- Content provided by FirstRanker.com ---
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener will be considered as malpractice, such answers will not becounted in marks and action will be taken according to UFM rules of university.
g)
Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
--- Content provided by FirstRanker.com ---
Q1. Total MCQs: 1010 x 1 = 10
1. Which of the following has the highest potential to cause metabolic syndrome?
(a) Clozapine
(b) Ziprasidone
--- Content provided by FirstRanker.com ---
(c) Haloperidol(d) Aripiprazole
2. Which of the following drugs is effective in both Grand Mal and Petit Mal Epilepsy?
(a) Phenobarbitone
(b) Phenytoin
--- Content provided by FirstRanker.com ---
(c) Carbamazepine(d) Sodium Valproate
3. Drug which is NOT used in a patient of severe complicated Falciparum malaria:
(a) Chloroquine
(b) Quinine
--- Content provided by FirstRanker.com ---
(c) Artesunate(d) Artemether
4. Which insulin analogue can be administered intravenously?
(a) Insulin Glargine
(b) Insulin Lispro
--- Content provided by FirstRanker.com ---
(c) Insulin Degludec(d) Insulin Detemir
5. Antipyretic Analgesic devoid of significant Anti-inflammatory effect is:
(a) Paracetamol
(b) Ketoprofen
--- Content provided by FirstRanker.com ---
(c) Piroxicam(d) Aspirin
6. Drug of choice for neutropenia due to cancer chemotherapy is:
(a) IL-11
(b) Erythropoietin
--- Content provided by FirstRanker.com ---
(c) Filgrastim(d) Vitamin-B12
7. ADR caused by bisphosphonates:
(a) Hepatotoxicity
(b) Esophageal Ulcers
--- Content provided by FirstRanker.com ---
(c) Tachycardia(d) Osteoporosis
8. Which local anesthetic agent is associated with a higher risk of methemoglobinemia?
(a) Bupivacaine
(b) Prilocaine
--- Content provided by FirstRanker.com ---
(c) Lidocaine(d) Procaine
9. Which class of antibiotics exhibits concentration-dependent killing and is characterized by a post-antibiotic
effect?
(a) Aminoglycosides
--- Content provided by FirstRanker.com ---
(b) Fluoroquinolones(c) Tetracyclines
(d) Macrolides
10. Which drug is a somatostatin analog used for the treatment of acromegaly and neuroendocrine tumors?
(a) Levothyroxine
--- Content provided by FirstRanker.com ---
(b) Desmopressin(c) Octreotide
(d) Insulin lispro
lOMoARcPSD|55903010
Q2. Long Answer Questions
--- Content provided by FirstRanker.com ---
2 x 20 = 40a. A 19-year-old man is brought to the OPD by his mother. He has been kicked out of the hostel for his "bizarre"
behavior. He has accused several fellow students and professors of spying on him for the CIA. He stopped
attending his classes and spends all of his time watching TV because the announcers are sending him secret
messages on how to save the world. He has stopped bathing and will only change his clothes once a week. His
--- Content provided by FirstRanker.com ---
physical examination and blood tests are normal. A drug screen is negative. You diagnose him with acutepsychosis secondary to schizophrenia, admit him to the psychiatric unit of the hospital, and start him on
haloperidol. (6+6+8=20)
1. What is the pharmacological basis of the use of Haloperidol in this condition?
2. What are the advantages of Atypical Antipsychotics over the Typical Antipsychotics?
--- Content provided by FirstRanker.com ---
3. Explain the important ADRs caused by Typical Antipsychotic drugs along with the treatment of thoseADRs.
b. A 58-year-old male weighing 55 kg presented with complaints of cough with expectoration, fever, and night
sweats since the last 4 weeks. He started experiencing shortness of breath since the last 4 days. X-ray chest
revealed a patchy area of consolidation. Sputum smear was positive for Acid Fast Bacilli. There is no previous
--- Content provided by FirstRanker.com ---
history of similar symptoms or treatment taken for Tuberculosis. He was prescribed treatment forTuberculosis based on NTEP guidelines. (4+10+6=20)
1. What is the Treatment Regime for Drug Susceptible Tuberculosis as per current NTEP Guidelines?
2. What is the basis of the use of these drugs in this regime? Enumerate the important ADRs of these drugs.
3. What do you mean by Drug Resistant Tuberculosis? Enumerate second-line Anti-TB Drugs.
--- Content provided by FirstRanker.com ---
Q3. Brief Answer Questions6 x 05 = 30
a. Explain why abrupt cessation of Glucocorticoids after prolonged therapy is not advised? Enumerate the long-
term ADRs of Corticosteroids.
b. Why are SSRIs preferred in patients of Depression over other drugs?
--- Content provided by FirstRanker.com ---
c. Rationale for using Low-dose Aspirin as an Antiplatelet drug.d. Describe the management of Diabetic Ketoacidosis.
e. Write regimes used for Emergency Contraception explaining their mechanism of action.
f. Enumerate drugs used and explain their mechanism for action in the prophylaxis of migraine.
Q4. Short Answer Questions
--- Content provided by FirstRanker.com ---
10 x 2 = 20a. Why Levodopa is not used in drug-induced parkinsonism?
b. Why Morphine is contraindicated in Head injury patients?
c. Why Oxytocin and not Ergometrine is used in Induction of Labour?
d. Write two drugs effective in the treatment of Methicillin-resistant Staphylococcal infections.
--- Content provided by FirstRanker.com ---
e. Drugs used in Acute attack of Migraine.f. Why Adrenaline is combined with Lidocaine?
g. Write the Preferred first-line ART regimen based on the National Programme.
h. Drugs used in Chronic Gout.
i. Write the Absolute Contraindications of Hormonal Oral Combined Contraceptive pills.
--- Content provided by FirstRanker.com ---
j. Obstetric Indications of Prostaglandins.