lOMoARcPSD|55903010
Madhya Pradesh Medical Science University, Jabalpur
MBBS Second Professional Examination April-2024
Subject- Pharmacology
Paper- I (new scheme)
Maximum Marks :100
Instructions:
a)
b)
Draw diagrams wherever necessary
c)
Answers of Questions and Sub-questions must be written strictly according to serial order of question paper.
MCQ has to be answered in theory answer book
e)
Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
counted in marks and action will be taken according to UFM rules of university.
g)
Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
10 x 1 = 10
1. For which of the following drugs a warning is written "To be sold by retail on the prescription of a Registered
Medical Practitioner only"?
(a) Schedule H
(c) Schedule Y
(d) Schedule J
2. Essential medicines are those medicines:
(a) That are needed to
(c) That satisfy the priority
(d) That are introduced
treat emergency
treat serious diseases
recently into the market
conditions
population
3. Which of the following agent is beneficial in NSAID induced gastric ulcer?
(b) PGE2 agonist
(c) PGD2 agonist
(d) PGF2a agonist
4. The success of oral rehydration therapy of diarrhea, depends upon which of the following process in the
(a) Na+ absorption by Na+
(b) Glucose coupled Na+
(c) Bicarbonate coupled
(d) Passive sodium
Na+ absorption
diffusion secondary to
nutrient absorption
5. The most important action of beta-blockers in glaucoma is which of the following:
(b) Retinal neuron
(c) Decrease production of (d) Pupillary constriction
effect
protecting effect
6. A 24-years-old farm worker is rushed to emergency department after an accidental exposure to parathion.
Which of the following drugs can be given to increase the activity of his acetyl cholinesterase?
(a) Atropine
(b) Dimercaprol
(d) Pralidoxime
7. Drug used in treatment of torsade de pointes:
(a) Quinidine
(b) Amiodarone
(d) Verapamil
8. In a patient with hypertriglyceridemia and low HDL, which of the following drug will be best without risk of
myocardial side effect?
(a) Fibric acid derivatives
(c) Atorvastatin
(d) Clofibrate
9. A patient of bronchial asthma was prescribed 2 puffs from a metered dose inhaler of budesonide. Which of the
following should NOT be done?
(b) Clean the inhaler after
(c) Wait for 1 minute in
(d) Rinse mouth after
before use
between puffs
every use
lOMoARcPSD|55903010
10. A 30 years old pregnant woman has a history of rheumatoid arthritis which has been managed successfully
worsened by food intake. Which of the following ulcer Medications is most likely contraindicated in this patient?
(a) Famotidine
(b) Omeprazole
(c) Misoprostol
Q2. Long Answer Questions
2 x 20 = 40
a. A 35-year-old woman was taking combined oral contraceptive pills. She was diagnosed as a case of Pulmonary
tuberculosis and put on isoniazid, rifampicin, pyrazinamide and ethambutol combination therapy daily for 2
failed to have withdrawal bleeding during the gap period of contraceptive cycle. Later her urinary pregnancy
test was found positive.
I What is the reason for contraceptive failure?
II Explain Phase I biotransformation reaction with suitable examples.
IV Explain microsomal enzyme inhibition with suitable examples.
b. A 70 years old male presented with complaints of weak stream of urine, sense of incomplete voiding and
increased urinary frequency. On physical examination and ultrasound, he was diagnosed as having benign
prostatic hyperplasia.
II What is the rationale of using these drugs in benign prostatic hyperplasia (BPH).
III Write down the mechanism of action and common side effects of these drugs.
IV What is the role of finasteride in the treatment of benign prostatic hyperplasia (BPH)
Q3. Brief Answer Questions
a. Enumerate Proton pump inhibitors with their therapeutic uses. Mention first line Anti H. pylori regimen.
b. Treatment of status asthmaticus.
c. Enumerate parenteral iron preparations. Mention in which condition iron therapy be administered by
injection route.
e. Classify loop diuretics. Enumerate therapeutic uses and adverse effects of loop diuretics.
f. Classify various dosage forms of drug. Write in brief about Tablets.
Q4. Short Answer Questions
10 x 2 = 20
b. Post marketing surveillance study.
c. Enumerate 02 differences between first and zero order kinetics.
d. Explain, why low dose of aspirin is used for myocardial infarction?
e. Name two anti-secretory anti motility drug for treatment of diarrhea.
preparations.
g. Enumerate 2 drugs used in the treatment of productive cough.
h. Role of nitrates in cyanide poisoning.
i. Enumerate 04 therapeutic uses of Fibrinolytics.
Madhya Pradesh Medical Science University, Jabalpur
MBBS Second Professional Examination April-2024
Subject- Pharmacology
Paper- I (new scheme)
--- Content provided by FirstRanker.com ---
Time: 3:00 HoursMaximum Marks :100
Instructions:
a)
--- Content provided by FirstRanker.com ---
All questions are compulsoryb)
Draw diagrams wherever necessary
c)
Answers of Questions and Sub-questions must be written strictly according to serial order of question paper.
--- Content provided by FirstRanker.com ---
d)MCQ has to be answered in theory answer book
e)
Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
--- Content provided by FirstRanker.com ---
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener will be considered as malpractice, such answers will not becounted in marks and action will be taken according to UFM rules of university.
g)
Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
--- Content provided by FirstRanker.com ---
Q1. Total MCQs: 1010 x 1 = 10
1. For which of the following drugs a warning is written "To be sold by retail on the prescription of a Registered
Medical Practitioner only"?
(a) Schedule H
--- Content provided by FirstRanker.com ---
(b) Schedule X(c) Schedule Y
(d) Schedule J
2. Essential medicines are those medicines:
(a) That are needed to
--- Content provided by FirstRanker.com ---
(b) That are needed to(c) That satisfy the priority
(d) That are introduced
treat emergency
treat serious diseases
--- Content provided by FirstRanker.com ---
health care needs of therecently into the market
conditions
population
3. Which of the following agent is beneficial in NSAID induced gastric ulcer?
--- Content provided by FirstRanker.com ---
(a) PGE1 agonist(b) PGE2 agonist
(c) PGD2 agonist
(d) PGF2a agonist
4. The success of oral rehydration therapy of diarrhea, depends upon which of the following process in the
--- Content provided by FirstRanker.com ---
intestinal mucosa?(a) Na+ absorption by Na+
(b) Glucose coupled Na+
(c) Bicarbonate coupled
(d) Passive sodium
--- Content provided by FirstRanker.com ---
absorptionNa+ absorption
diffusion secondary to
nutrient absorption
5. The most important action of beta-blockers in glaucoma is which of the following:
--- Content provided by FirstRanker.com ---
(a) Membrane stabilizing(b) Retinal neuron
(c) Decrease production of (d) Pupillary constriction
effect
protecting effect
--- Content provided by FirstRanker.com ---
aqueous humor6. A 24-years-old farm worker is rushed to emergency department after an accidental exposure to parathion.
Which of the following drugs can be given to increase the activity of his acetyl cholinesterase?
(a) Atropine
(b) Dimercaprol
--- Content provided by FirstRanker.com ---
(c) Physostigmine(d) Pralidoxime
7. Drug used in treatment of torsade de pointes:
(a) Quinidine
(b) Amiodarone
--- Content provided by FirstRanker.com ---
(c) Isoprenaline(d) Verapamil
8. In a patient with hypertriglyceridemia and low HDL, which of the following drug will be best without risk of
myocardial side effect?
(a) Fibric acid derivatives
--- Content provided by FirstRanker.com ---
(b) Nicotinic acid(c) Atorvastatin
(d) Clofibrate
9. A patient of bronchial asthma was prescribed 2 puffs from a metered dose inhaler of budesonide. Which of the
following should NOT be done?
--- Content provided by FirstRanker.com ---
(a) Shake the inhaler well(b) Clean the inhaler after
(c) Wait for 1 minute in
(d) Rinse mouth after
before use
--- Content provided by FirstRanker.com ---
every usebetween puffs
every use
lOMoARcPSD|55903010
10. A 30 years old pregnant woman has a history of rheumatoid arthritis which has been managed successfully
--- Content provided by FirstRanker.com ---
with NSAIDs. However, she has recently visited her general practitioner complaining of burning epigastric painworsened by food intake. Which of the following ulcer Medications is most likely contraindicated in this patient?
(a) Famotidine
(b) Omeprazole
(c) Misoprostol
--- Content provided by FirstRanker.com ---
(d) RanitidineQ2. Long Answer Questions
2 x 20 = 40
a. A 35-year-old woman was taking combined oral contraceptive pills. She was diagnosed as a case of Pulmonary
tuberculosis and put on isoniazid, rifampicin, pyrazinamide and ethambutol combination therapy daily for 2
--- Content provided by FirstRanker.com ---
months followed by isoniazid and rifampicin thrice weekly for 4 months. In the 3rd month of treatment, shefailed to have withdrawal bleeding during the gap period of contraceptive cycle. Later her urinary pregnancy
test was found positive.
I What is the reason for contraceptive failure?
II Explain Phase I biotransformation reaction with suitable examples.
--- Content provided by FirstRanker.com ---
III Explain Microsomal Enzyme Induction.IV Explain microsomal enzyme inhibition with suitable examples.
b. A 70 years old male presented with complaints of weak stream of urine, sense of incomplete voiding and
increased urinary frequency. On physical examination and ultrasound, he was diagnosed as having benign
prostatic hyperplasia.
--- Content provided by FirstRanker.com ---
I Enumerate 05 drugs used in the treatment of benign prostatic hyperplasia (BPH).II What is the rationale of using these drugs in benign prostatic hyperplasia (BPH).
III Write down the mechanism of action and common side effects of these drugs.
IV What is the role of finasteride in the treatment of benign prostatic hyperplasia (BPH)
Q3. Brief Answer Questions
--- Content provided by FirstRanker.com ---
6 x 05 = 30a. Enumerate Proton pump inhibitors with their therapeutic uses. Mention first line Anti H. pylori regimen.
b. Treatment of status asthmaticus.
c. Enumerate parenteral iron preparations. Mention in which condition iron therapy be administered by
injection route.
--- Content provided by FirstRanker.com ---
d. Classify Anti-Hypertensive Drugs. Enumerate drug used in hypertension during pregnancy.e. Classify loop diuretics. Enumerate therapeutic uses and adverse effects of loop diuretics.
f. Classify various dosage forms of drug. Write in brief about Tablets.
Q4. Short Answer Questions
10 x 2 = 20
--- Content provided by FirstRanker.com ---
a. Enumerate 04 therapeutic uses of centrally acting skeletal muscle relaxants.b. Post marketing surveillance study.
c. Enumerate 02 differences between first and zero order kinetics.
d. Explain, why low dose of aspirin is used for myocardial infarction?
e. Name two anti-secretory anti motility drug for treatment of diarrhea.
--- Content provided by FirstRanker.com ---
f. Explain pharmacological basis of combination of Calcium and Magnesium salts in most of antacidpreparations.
g. Enumerate 2 drugs used in the treatment of productive cough.
h. Role of nitrates in cyanide poisoning.
i. Enumerate 04 therapeutic uses of Fibrinolytics.
--- Content provided by FirstRanker.com ---
j. Mechanism of action of osmotic diuretics.