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EXAMINATION OCTOBER 2024 (Supplementary Exam)
FIRST MBBS
BIO-CHEMISTRY ( PAPER - II ) ( NEW ) - LEVEL 3
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[Time: As Per Schedule][Max. Marks:100 ]
Instructions:
Seat No:
1. Fill up strictly the following details on your answer book
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a. Name of the Examination : BACHELOR OF MEDICINE ANDBACHELOR OF SURGERY (FIRST)
b. Name of the Subject : BIO-CHEMISTRY ( PAPER - II )
(Level-3 )
c. Subject Code No : 2406000101030702-A
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2. Sketch neat and labelled diagram wherever necessary.3. Figures to the right indicate full marks of the question.
4. All questions are compulsory.
Student's Signature
Section ?A
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Q.1 Multiple choice questions (20 out of 20)
20
1. Which of the following trace element has an antioxidant role?
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a. Selenium b. Nickle c. Chromium d. Zinc2. Urine of a 12 years old boy gave a positive cyanide-nitroprusside test. He
had renal stones. He is likely to have:
a. Homocystinuria b. Cystinosis
c. Hartnup's disease d. Renal glycosuria
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3. Biotin is inhibited by:a. Isoniazid (INH) b. Methotrexate c. Dicoumarol d. Avidin
4. Ammonia is trapped in brain by:
a. Glutamine synthetase reaction b. Glutaminase reaction
c. Urea synthesis cycle d. Glutamate dehydrogenase reaction
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5. Wernicke's disease & Beri Beri can be treated by administering:a) Thiamine b) Niacin c) Folic Acid d) Riboflavin
6. Minamata disease is caused by:
a) Lead Poisoning b) Mercury Poisoning
c) Aluminum Toxicity d) Arsenic Toxicity
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7. Immunoglobulin present in secretions is:a) IgA b) IgM c) IgE d) IgG
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8. Reversal of A/G ratio is seen in:a) Cirrhosis of liver b) Nephrotic Syndrome
c) Dehydration d) Both A & B
9. The two nitrogen atoms of urea are
a) Aspartate and glutamate b) Aspartate and ammonia
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c) Fumarate and aspartate d) Ammonia and glutamate10.
Which of the following nucleotide acts as second messanger in
eliciting the hormonal action
a) NAD+ b) B SAM c) ADP d) CAMP
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11.Ammonia from brain is detoxified Gamma cysteinyl glycine is other
a) Bradykinin b) Angiotensin c) Glutathione d) Oxytocin
12.
The photosensitivity is not a feature of which of the following
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porphyriaa) Congenital erythropoetic porphyria
b) Porphyria cutenia tarda
c) Acute intermittent porphyria
d)Varigate porphyria
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13.Which of the following enzyme is associated with the salvage
pathway of purine nucleotide
a) Ribonucleoside reductase b) Cyclohydrolase
c) PRPP synthase d) HGPRT
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14.Which of the following trace element has an antioxidant role?
a. Selenium b. Nickle c. Chromium d. Zinc
15.
The chief product of catabolism of purine in human being is
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a. Urea. b. Urica acidc. Hypoxanthine d. Beta aminoisobutyric
16.
The drug of choice for primary gout is:
a. Allopurinol b. Aspirin
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c. Colchicine d. Probenecid17.
Which protein is not present in plasma?
a.Albumin. b. Fibrinogen
c. Hemoglobin. d. Globulins
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18.Genu valgum and Genu varus are characteristic feature of,
a. Vitamin A deficiency b. Vitamin K deficiency
c. Niacin deficiency d. Vitamin D deficiency
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Triangular plaque or Bitot's spot is commonly seen in-
a. Retinol deficiency
b. Retinol toxicity
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c. Diabetic retinopathyd. Conjunctivitis
20.
Amino acid used for the synthesis of serotonin hormone is -
a. Tyrosine b. Tryptophan c. Histidine d. Proline
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Section ?B
Q.2 Long Answer Questions (2 out of 3)
40
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2x10=201. Explain eukaryotic DNA organization. Add a note on eukaryotic cell cycle.
Describe the role of various eukaryotic DNA polymerases. Describe DNA
repair mechanisms with disorders. (3+2+2+3).
2. Draw oxygen dissociation curve and explain right & left shift of ODC with
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factors affecting it. Describe molecular defect, reason for sickle-shaped RBCs,clinical features, diagnosis and management of sickle cell disease
.
3. Describe the complete degradation of Heme. Describe various types of
Jaundice, causes, clinical features and the biochemical parameters used for
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their diagnosis.Q.3 Short Answer Questions (10 out of 11)
10x2=20
1) Draw well labeled diagram of induction and repression of Lac-operon
2) Why does albumin level decrease in cirrhosis of the liver and nephrotic
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syndrome?3) Write deficiency disorders of any four water-soluble vitamins with at
least three clinical features each.
4) Define Isoenzymes. Give clinical significance of isoenzymes of LDH
5) What are tumor markers? Give 2 examples
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6) Glutathione is important for maintaining RBCs membrane integrity7) Sickle Hb tends to polymerize in deoxygenated state.
8) Genetic code is universal with few exceptions.
9) Discuss role of acute phase proteins in health and disease.
10) Effect of pH, pCO2, 2-3-BPG & temperature on ODC curve.
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11) Telomerase are involved in aging process. JustifySection C
Q.4 Short Answer Questions (4 out of 5)
4x5=20
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1) Describe competitive, non-competitive, and uncompetitive enzymeinhibition with clinical significance. (2+1.5+1.5)
2) Describe steps and clinical applications of DNA recombinant technology
(3+2)
3) Describe post-translational modifications with examples
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4) Enumerate cardiac biomarkers in the order of their earliest rise inmyocardial infarction. Describe cardiac biomarkers that are not enzymes
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5) write note on Genetic code
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Q.5Clinical Cases (2 out of 2)
2x10=20
Case-1
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A 5-year-old vegetarian boy was brought to pediatric OPD by his mother withthe complains of unable to see at night, growth retardation and irritability. On
examination his weight is less than his chronological age. There are greyish
white spots on lateral sides of both corneas. The patient was diagnosed having
Vitamin A deficiency.
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Questions:Q-1 Name the ocular signs and symptoms of vitamin A deficiency according to
sequence of their appearance.
Q-2 Draw Wald's visual cycle.
Q-3 Why obstructive jaundice patients may develop night blindness?
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Q-4 Write functions & mechanism of action of retinoic acid.Q-5 Write dietary advice to this patient to correct vitamin A deficiency.
Case-2
A 70 years old man presented with back pain, loss of weight and breathlessness.
On examination, he was anemic. Investigations showed: Hb 8gm/dl, total
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proteins 10.5 gm/dl, albumin 2.5 gm/dl, urea 50 mg/dl, and creatinine 2.3mg/dl.Serum protein electrophoresis showed M band in region. In urine, Bence Jones
proteins were present. Radiological examination showed punched out lytic
lesions in lumbar vertebrae, ribs & pelvis. Diagnosis of Multiple Myeloma was
made.
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1. What is the principle of electrophoresis?2. What is the normal pattern of serum proteins in electrophoresis?
3. Calculate A/G ratio in this patient. Name various other conditions which
alter A/G ratio.
4. What are Bence Jones proteins? How are they detected in urine?
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5. Enumerate the functions of immunoglobulin.*****
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