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(SUPPLIMENTARY EXAM) FEBRUARY-2025
SECOND MBBS
PHARMACOLOGY ( PAPER - I ) ( NEW ) (OMR)
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[Time: As Per Schedule][Max. Marks: 100]
Instructions:
Seat No:
1. Fill up strictly the following details on your answer book
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a. Name of the Examination : SECOND MBBSb. Name of the Subject : PHARMACOLOGY ( PAPER - I )
( NEW ) (OMR)
c. Subject Code No : 2406000102010501-S
2. Sketch neat and labeled diagram wherever necessary.
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Student's Signature3. Figures to the right indicate ful marks of the question.
4. Al questions are compulsory.
5. Frist 20 mins has been alotted for MCQs.
6. Answers must be brief, precise and to the point.
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Section I
Q.1 Multiple choice questions (MCQs)
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(Each Question Carries one mark and there is no negative marking)1. Which of the following agent binds to GABA receptor Chloride
channel complex?
a) Ethanol
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b) Alphaxolonc) Zolpidem
d) Buspirone
2. Alpha-receptor stimulation includes all of the following effects
EXCEPT:
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a) Relaxation of gastrointestinal smooth muscleb) Contraction of bladder base, uterus and prostate
c) Stimulation of insulin secretion
d) Stimulation of platelet aggregation
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[1 of 8]3. Which of the following agents enhances the bioavailability of
Levodopa in patients with Parkinson's disease:
a) Amantadine
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b) Ropinirolec) Entacapone
d) Selegiline
4. Mechanism of action of Mianserin:
a) Inhibits alpha-adrenergic, H1, and some types of serotonin
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receptors.b) Inhibits alpha-adrenergic, H2, and some types of serotonin
receptors.
c) Inhibits beta-adrenergic, H1, and some types of serotonin
receptors.
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d) Inhibits alpha- adrenergic and H1 receptors.5. Omalizumab is indicated for which of the following conditions:
a) Multiple myeloma
b) Psoriasis
c) Bronchial Asthma
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d) Rheumatoid Arthritis6. Which of the following drug undergoes Hoffman's elimination?
a) Atracurium
b) Pancurinium
c) Mivacurium
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d) Vecuronium7. Which of the following is an example of physiological antagonism?
a) Heparin-protamine
b) Prostacycline-thromboxene
c) Adrenaline-phenoxybenzamine
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d) Physostigmine-Acetylcholine8. Following are uses of anticholinesterases. EXCEPT.
a) Alzheimer's disease
b) Myasthenia gravis
c) Organophospharus poisoning d) Glaucoma
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9. A 3-year-old child was undergoing squint surgery, initial heart rate
was 140 beats per min. after anaesthesia and start of surgery heart
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rate dropped to 40 beats/min. what should be the next step?a) Stop surgery
b) Decrease plane of anaesthesia
c) Inj glycopyrrolate d) Inj atropine
10. Which of the following does not potentiate the action of neuro-
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muscular blocker?a) Hypothermia
b) pH changes
c) Halothane
d) Hyperkalaemia
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11. After which phase of clinical trial a new drug is marketed?a) Phase I
b) Phase II
c) Phase III
d) Phase IV
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12. For pre-anesthetic medication all drugs can be used EXCEPT.a) Diazepam
b) Glycopyrrolate
c) Metoclopramide
d) Phenobarbitone
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13. Which of the following drug is effective in painful tinglingsensation due to diabetic neuropathy:
a) Aspirin
b) Ibuprofen
c) Gabapentin
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d) Tramodol14. Drug of choice for myoclonic seizures is:
a) Valproic acid
b) Phenytoin
c) Ethosuximide
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d) Carbamazepine15. Which of the following agent is used for acute iron poisoning?
a) Penicillamine
b) Deferasirox
c) Desferioxamine
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d) Dimercaprol2406000102010501-S
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16. Alkaline diuresis is done for treatment of poisoning due to:
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a) Barbituratesb) Morphine
c) Amphetamine
d) Ethyl alcohol
17. Which of the following statement is wrong about Buspirone?
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a) It doesn't produce withdrawal symptoms on stoppage.b) It doesn't produce sedation
c) It has anticonvulsant action
d) It has no muscle relaxant activity
18. Inverse agonist has
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a) Affinity but no intrinsic activityb) Affinity and submaximal intrinsic activity
c) Affinity but intrinsic activity with minus sign
d) Both affinity and maximal intrinsic activity
19. A young patient is being treated for myasthenia gravis, which
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requires frequent adjustment of the optimal dose of Neostigmine.The patient is challenged with Edrophonium to evaluate the
effectiveness of the cholinesterase inhibition. Optimal dosing will
be indicated by
a) An increase in muscle strength
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b) A decrease in muscle strengthc) No change in muscle strength
d) Initially increase and later on decrease in muscle strength
20. A 3 year old child presented to OPD with the symptoms of
influenza. Aspirin is contraindicated in this patient because of
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increased risk ofa) Gastric bleeding
b) Thrombocytopenia
c) Fanconi syndrome
d) Reye's syndrome
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Q.2 Answer in Brief [any Five]:
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a. Explain the first order kinetics and zero order kinetics with suitablediagram and examples.
b. Compare and contrast depolarizing and non-depolarizing
neuromuscular blockers.
c. Write advantages of atypical antipsychotics. Explain in brief about
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extrapyramidal side effects of antipsychotics.d. Write a note on triptans.
e. Give rationale behind: (A) Tamsulosin in benign prostate
hypertrophy (B) Colchicine in acute gout.
f. Classify DMARDs. Explain the role of methotrexate in rheumatic
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arthritis.Q.3 Write answer in details [any three]:
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a. Describe adverse effects, contraindications, and therapeutic uses of
- blockers.
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b. Classify anticholinergic drugs. Describe the treatment of smokingcessation.
c. Classify antiepileptic drugs. Describe adverse effects of phenytoin
and valproic acid. Write down the treatment of febrile convulsion.
d. Describe various factors that modifying drug actions.
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Q.4 Answer the following based on given case scenario.
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A 40-year-old patient known case of moderate chronic asthma with
frequent exacerbation, brought to the emergency department with
severe breathlessness. Patient took MDI Salbutamol at home, but it did
not relieve the symptoms. Patient was on MDI FORACORT
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(Formoterol + Budesonide) BD from last 6 months. Patients' currentdiagnosis is status asthmaticus. Answer the following.
a. Classify anti-asthmatic drugs Describe the drug therapy for status
asthmaticus with its pharmacological basis.
b. What is the rationale behind the Formoterol + Budesonide
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combination?c. Write down adverse effects of inhaled corticosteroids and how it
can be minimized?
Section II
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Q.5 Answer in Brief [any Five]:
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1. Write a note on drug antagonism.
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2. Which are the distinctive features of second generation anti-histaminic? Explain the role of cinnarizine in vertigo.
3. Describe pharmacotherapy of methanol poisoning.
4. Which are specific antidotes of acute anticholinesterase poisoning?
Write the rationale of using these drugs.
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5. Describe pharmacological basis of aspirin in myocardial infarction
and preeclampsia. Enumerate its contraindications.
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6. Why local anesthetics should not use in inflamed tissue? Commenton addition of adrenaline to local anesthetics.
Q.6 Write answer in details [any three]:
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a. Describe adverse effects, contraindications/precautions, and
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therapeutic uses of morphine.b. List sympathomimetic drugs. Describe therapeutic uses of adrenalin
with pharmacological basis.
c. Classify antidepressant drugs. Describe adverse effects of TCAs.
List the uses of SSRIs.
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d. Define Pharmacovigilance and adverse drug reactions. Explain inbrief about drug withdrawal reactions and teratogenicity with
appropriate examples.
Q.7 Answer the following based on given case scenario.
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A 62-year female patient came to OPD with complaint of tremors inhands that also occurs during rest, difficulty walking, problems with
coordination and difficulty speaking for 3 months. Patient diagnosed
with Parkinson's diseases. Patient prescribed with combination of
levodopa 100 mg + carbidopa 10 mg tablets once a day. Answer the
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following:2406000102010501-S
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A. Classify the drug's use for Parkinson's diseases
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B. Describe in detail about various adverse effects of levodopatherapy
C. Describe benefits and drawbacks of levodopa and carbidopa
combination
D. Which drugs produce Parkinson's like symptoms? Which drugs
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are given in treatment of drug induced Parkinsonism.*****
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