2406000102010502-S
(SUPPLIMENTARY EXAM) FEBRUARY-2025
SECOND MBBS
PHARMACOLOGY (PAPER - II) (NEW) (OMR)
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[Time: As Per Schedule][Max. Marks: 100]
Instructions:
Seat No:
1. Fill up strictly the following details on your answer book
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a. Name of the Examination: SECOND MBBSb. Name of the Subject: PHARMACOLOGY (PAPER - II) (NEW)
(OMR)
c. Subject Code No: 2406000102010502-S
2. Sketch neat and labeled diagram wherever necessary.
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3. Figures to the right indicate ful marks of the question.4. Al questions are compulsory.
5. Answers should be precise and to the point.
Student's Signature
6. First 20 mins have been alotted to solve multiple choice questions.
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SECTION - I
Q.1 Multiple choice questions (MCQs)
1?20=20
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(Each question carries one mark and there is no negative marking.)1. Which amongst the following antimicrobials exhibits a long post
antibiotic effect?
a) Fluorouinolones
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b) Macrolidec) Beta-lactams
d) Oxazolidinones
2. Tadalafil should not be used in
a) Diabetics b) Patient on vasodilator therapy
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c) Pulmonary hypertension d) Erectile dysfunction3. Which of the following pair is correct for heavy metals and their
chelating agents?
a) Iron ? BAL
b) Mercury-Calcium disodium edetate
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c) Copper ? d-penicillamined) Arsenic ? Deferasirox
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4. Which of the following is pure bradycardia drug?a) Verapamil b) Acebutolol c) Ivabradine d) Amiodarone
5. A 30-year-old pregnant woman has a history of rheumatoid arthritis
which has been Managed successfully with NSAIDS. However, she
has recently visited her general practitioner complaining of burning
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epigastric pain worsened by food intake. Which of the followingantiulcer drug is most likely contraindicated in this patient:
a) Famotidine
b) Omeprazole
c) Misoprostol
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d) None of the above6. Which of the following purgative increases the faecal bulk due to
their water absorbing and retaining capacity?
a) Methyl cellulose
b) Lactulose
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c) Liquid paraffind) Dioctyl sodium sulfosuccinate
7. Ciprofloxacin should not be given to an asthmatic using
theophylline because:
a) Ciprofloxacin decreases effects of theophylline
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b) Theophylline induces metabolism of ciprofloxacinc) Ciprofloxacin inhibits theophylline metabolism
d) Theophylline inhibits ciprofloxacin metabolism
8. In post MI patient which dose of aspirin is recommended?
a) 20 ? 50 mg/day b) 75 ? 150 mg/day
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c) 500 ? 1000 mg/day d) 3000 ? 4000 mg/day9. Drug of choice for bleeding oesophageal varices is:
a) Ethanolamine oleate
b) Octreotide
c) propranolol
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d) phytonadione10. In which of the following disease is corticosteroids indicated?
a) Osteoporosis
b) peptic ulcer
c) Neurocysticercosis
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d) kala-azar11. Methotrexate is used for the management of all of these conditions
except:
a) Rheumatoid arthritis b) Psoriasis
c) Leukopenia d) Organ transplantation
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12. A 17-year-old girl had been taking a drug for treatment of acne for
the last 2 years, which has led to pigmentation. Which drug could it
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be?a) Doxycycline
b) Azithromycine
c) Minocycline
d) Chlorpromazine
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13. Drug of choice for syphilis is:a) Penicillin b) Rifampicin c) Tetracycline d) Erythromycin
14. Which of the following antibiotic is used in the treatment of
Clostridium difficile associated diarrhoea?
a) Ciprofloxacin
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b) Metronidazolec) Piperacillin
d) Clindamycin
15. Which of the following is valid indication for intramuscular iron
therapy?
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a) Pregnancy b) Postpartum periodc) Emergency surgery d) Oral iron intolerance
16. Tirofiban is:
a) Monoclonal antibody b) Antiplatelet drug
c) Anti-inflammatory drug d) Antianginal drug
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17. Which of the following is the correct match about vitamin and itspreferred use?
a) Retinol- Alcoholic neuritis
b) Cholecalciferol- Psoriasis
c) Niacin- Hyperlipidaemia
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d) Ascorbic acid- Peripheral neuropathy18. Ulipristal is
a) A synthetic progesterone
b) An antiprogesterone
c) A selective progesterone receptors modulator
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d) A selective estrogen receptor modulator19. Following drugs can cause gynaecomastia, except
a) Cimetidine b) Spironolactone c) Finasteride d) Fluconazole
20. Which of the following SERM useful for treatment of osteoporosis?
a) Estradiol b) Bisphosphonate c) Strontium d) Raloxifene
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Q.2 Answer in Brief [any Five]:
3?5=15
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a) Explain chemoprophylaxis against specific organisms by givingsuitable examples.
b) Classify calcium channel blockers (CCBs). Why is nimodipine
prescribed in subarachnoid haemorrhage?
c) Compare and contrast: Metoclopramide and Domperidone.
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d) What is "relapse" in relation to malaria? Write drug therapy forrelapsing malaria.
e) Give reason:
A. Chloroquine is useful in hepatic amoebiasis but not in
intestinal amoebiasis.
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B. Albendazole is preferred over praziquantel for the treatmentof neurocysticercosis.
f) Explain two commonly employed "insulin regimens for diabetes"
with suitable diagram
Q.3 Write answer in details [any three]:
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5?3=15a) Classify drugs used in Congestive Cardiac Failure (CCF). Write
current status of digoxin in therapy of CCF. Point out any two
drugs along with its pharmacological basis which arrest/reverse
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disease progression for the same?b) Describe various complications and interactions of high ceiling
diuretics. Elaborate role of spironolactone in cirrhotic oedema.
c) Classify thyroid inhibitors. Describe mechanism of action, two
important adverse effects and indications of Propylthiouracil.
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d) Enumerate Thrombolytics. Describe its mechanism and role inpharmacotherapy of acute myocardial infarction (MI). Write
contraindications of thrombolytic therapy.
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Q.4 Answer the following based on given case scenario.
10?1=10
A 45-year-old male patient comes with complains of polyuria and weight
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gain (90 kg). His FBS and PP2BS were 140 mg/dl and 200mg/dl
respectively. while HbA1C was 6.7%. He was diagnosed as Type II
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Diabetes mellitus (DM). he was advised diet, exercise and other life stylemodifications. Answer the following questions regarding management of
this case.
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a) Which oral antidiabetic drug will you prescribe for this patient?
2
Why?
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b) Explain mechanism of action of drug which you have prescribed.
2
c) Write treatment strategy of Type II Diabetes Mellitus. (Explain
2
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with flowchart)d) If above mentioned patient skipped his meal after taking
2
antidiabetic drug, what could happen to him? and how will you
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manage this condition?
e) How dapagliflozin and sitagliptin are beneficial in DM.
2
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SECTION - IIQ.5 Answer in Brief [any Five]:
3?5=15
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a) Write short note on "Integrase Inhibitors".b) Classify anti-leprotic drugs. Describe pharmacotherapy of
multibacillary leprosy as per NLEP guideline.
c) Write pharmacological basis for:
i. Thiazides in diabetes insipidus
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ii. Dopamine in cardiogenic shockd) Name two "Nitric Oxide (NO) donor". Describe therapeutic uses of
any one of them.
e) Elaborate use of Probiotics in diarrhoea.
f) Compare and contrast: Oxytocin and Ergometrine.
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Q.6 Write answer in details [any three]:
5?3=15
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a) Enlist various drugs from different categories for Hypertension.
Write merits and demerits of any two 1st line antihypertensive
drugs. Outline pharmacotherapy of Hypertensive emergency.
b) What is "Hormone Replacement Therapy (HRT)"? Describe HRT
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in post-menopausal women.c) Enlist Fluoroquinolones. Outline Pharmacotherapy of Urinary tract
infection.
d) Classify extended spectrum penicillins. Describe mechanism of
action,
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adverseeffects
and
therapeutic
uses
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ofampicillin/amoxicillin.
Q.7 Answer the following based on given case scenario.
10?1=10
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A 35-year-old male presented to TB and Chest department withcomplaints of low-grade fever, weight loss, productive cough, night
sweats and fatigue since more than 2 weeks. Patient's current weight is 56
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kg. He is diagnosed as drug sensitive tuberculosis. The patient resides with
his wife and two children (aged 7 and 4 years respectively). He had history
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of alcohol for 6 years.a) Which TB regimen should be started in this patient? Write one
2+2
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important adverse effect of each drug which you mentioned in thisregimen.
b) Is prophylaxis required in this case? To whom and why is it
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2required?
c) What is Tuberculosis preventive treatment (TPT)? Write two TPT
1+3
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regimens used under NTEP.*****
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