Download VNSGU MBBS 2nd Year 2024 January New 2406000102020601 S Pathology Paper I Feb 2025 mcq Question Paper

2406000102020601-S
(SUPPLIMENTARY EXAM) FEBRUARY-2025
SECOND MBBS
PATHOLOGY ( PAPER - I ) ( NEW ) (OMR)

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[Time: As Per Schedule]
[Max. Marks:100]
Instructions:
Seat No:
1. Fill up strictly the following details on your answer book

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a. Name of the Examination: SECOND MBBS
b. Name of the Subject: PATHOLOGY (PAPER - I) (NEW)
(OMR)
c. Subject Code No: 2406000102020601-S
2. Sketch neat and labelled diagram wherever necessary.

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3. Figures to the right indicate full marks of the question.
4. All questions are compulsory.
Student's Signature

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SECTION -I
Q.1 Multiple choice questions (*no negative markings)
20
Each Question Carries One mark.

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1. All infarcts are usually:
A. Wedge shaped.
B. Square shaped
C. Rectangular shaped
D. Circular in shape

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2. Most common opportunistic lung infection in AIDS patient is
A. Pneumocystis carinii
B. Kaposi sarcoma
C. candidiasis
D. Histoplasmosis.

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3. IgE mediated allergy / Asthma is example of which hypersensitivity
reaction
A. Type-l
B. Type-II
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C. Type-III
D. Type-IV.
4. The most common route of spread of infection to the brain is:

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A. Via venous route
B. Via arterial route
C. Via lymphatics
D. Along nerves
5. Test useful for detection of HIV during window period:

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A. ELISA
B. Western blot
C. CD4+ cell count
D. p24 antigen capture assay
6. Dystrophic calcification in Spleen is seen in which disease.

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A. Sickle cell disease
B. Left Heart Failure
C. Fatty Liver
D. ARDS.
7. Diabetic foot is an example of:

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A. Dry gangrene
B. Wet gangrene
C. Gas gangrene
D. Necrotising inflammation
8. Interstitial fluid collection during Congestive cardiac failure is called

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A. Cystic collection
B. Exudate
C. Edema
D. Effusion.
9. Haematoxylin stains:

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A. Nuclear chromatin material B. RNA
C. Cytosolic components
D. Cell membrane components.
10. Most Important Antigen initiating graft rejection.
A. P24 Ag

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B. polysaccharide
C. HLA antigen
D. TCR.
11. Type of Necrosis in pancreatitis:
A. Fat

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B. Fibrinoid
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C. Caseus

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D. Coagulative
12. Which of the following is an Apoptosis inhibitor gene?
A. BCL-2
B. Rb
C. P53

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D. C-Myc
13. Out of various free radical species, the following radical is most
reactive:
A. Superoxide (O2')
B. Hydrogen peroxide (H2O2)

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C. Hydroxyl (OH-)
D. Nitric oxide (NO)
14. Correct sequence of Cell cycle is
A. G0-M-G2-S-G1
B. G0-G1-G2-S-M

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C. G0-G1-S-G2-M
D. G0-G1-S-M-G2
15. For karyotyping, the dividing cells are arrested by Addition of
colchicine in the following mitotic phase:
A. Prophase

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B. Metaphase
C. Anaphase
D. Telophase
16. For Electron Microscopy Histopathology specimen are fixed in
A. Glutaraldehyde

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B. 10% Ethyl alcohol
C. 10% picric acid
D. 10% buffered neutral formalin
17. Enzyme which prevents ageing is:
A. Catalase

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B. Superoxide dismutase
C. Metalloproteinase
D. Telomerase
18. Bombay Blood group person have following ABO Blood group
A. "A" group

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B. "B" group
C. "O" group
D. "H" group
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19. Basement membrane consists of:
A. Type I collagen
B. Type II collagen
C. Type III collagen

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D. Type IV collagen
20. All are autosomal dominant inherited cancer syndromes except:
A. Retinoblastoma
B. Xeroderma pigmentosum
C. HNPCC

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D. Neurofibromatosis.


SECTION -II
Q.2 Case based long essay questions

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[13*1=13]


A 40-year-old male who had a history of road traffic accident presented to the

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clinic with polytrauma and left thigh swelling.

Patient was not able to walk.

His x-ray showed comminuted displaced fracture of the shaft femur. After 2

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days he developed sudden shortness of breath, confusion, and vomiting, He

also developed petechial rashes

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Lab findings - microscopic examination of urine showed fat globules.


1) What is your diagnosis based on the above clinical finding and lab
02

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investigation?

02
2) Describe aetiology and pathogenesis of given condition

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3) Write consequences of given condition
04
4) Describe difference between Arterial thrombi and Venous thrombi
05

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Q.3 Long essay questions. (Attempt any three)
9*3=27


1) Define oedema. Discuss pathophysiology of oedema. Add a note on

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[4+3+2]
pulmonary oedema.

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2) Define Hypersensitivity reactions. Describe etiology, pathogenesis, and
[1+2+4+2]
examples of Type- 4 Hypersensitivity reactions.

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3) Define Inflammation. Write in detail about vascular and cellular
[4+3+2]
changes in inflammation.

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4) Describe etiology of Cell injury. Describe morphology of Cell injury.
[3+6]


SECTION-III

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Q.4 Short notes (Attempt Any 8)
[8*5=40]

1) Three opportunistic infections and two neoplasms associated with
AIDS.

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2) Microscopic Findings of Urine in Various Diseases.
3) Describe CSF picture in Pyogenic meningitis.
4) Down's syndrome.
5) Viral oncogenesis.
6) Septic shock

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7) Enumerate Blood components and mention their uses and storage.
8) Granulomatous inflammation.
9) Etiopathology and sequelae of Obesity.
10) FISH (Fluorescence in situ Hybridization).
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