Download VNSGU MBBS 1st Year New 2406000101030701 A Bio Chemistry Paper I Oct 2024 Question Paper

2406000101030701-A
EXAMINATION OCTOBER 2024 (Supplementary Exam)
FIRST MBBS
BIO-CHEMISTRY ( PAPER - I ) ( NEW ) - LEVEL 3

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[Time: As Per Schedule]
[Max. Marks: 100]
Instructions:
Seat No:
1. Fill up strictly the following details on your answer book

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a. Name of the Examination: BACHELOR OF MEDICINE AND
BACHELOR OF SURGERY (FIRST)
b. Name of the Subject: BIO-CHEMISTRY ( PAPER - I ) ?Level-3
c. Subject Code No: 2406000101030701-A
2. Sketch neat and labelled diagram wherever necessary.

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3. Figures to the right indicate full marks of the question.
4. All questions are compulsory.
Student's Signature
SECTION-A

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Q.1 Multiple choice questions (20 out of 20)
20
1. Which of the following enzymes, does not play a role by eliminating the
free radicals from the biological sssystem?
a) Synthase

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b) Superoxide dismutase
c) Catalase
d) Glutathione peroxidase
2. The oxidation of NADH & FADH2 Through ETC yields about
a) 2.5 and 1.5 ATP respectively

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b) 3 and 2 ATP respectively
c) 1.5 and 2.5 ATP respectively
d) 2 and 3 ATP respectively
3. Which one of the following molecules acts as a methyl donor in
detoxification by Conjugation

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a) SAM
b) GSH
c) PAPS
d) All the above
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4. End product of glycolysis in aerobic and anaerobic respectively
a) Pyruvate, Lactate
b) Lactate, Pyruvate

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c) Fumarate, Ketoglutarate
d) Ketoglutarate, Fumarate
5. Von-gieake Disease is due to which enzyme defied
a) Glycogen Synthase
b) Transketolase

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c) Pyruvate kinase
d) Glucose-6-phosphatase
6. The number of cycles required to synthesize palmitate is
a) 5
b) 6

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c) 7
d) 9
7. Which of the following enzymes were used as markers of Hepatocellular
injury
a) ALP & GGT

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b) ALT & AST
c) LDH & CPK
d) None of above
8. Which of the following is not the disease associated with the
abnormalities of membrane proteins?

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a) Wilson disease
b) Familial hypercholesterolemia
c) Diabetes mellitus
d) Cystic fibrosis
9. Which of the following is not an example of factors promoting Calcium

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absorption?
a) Vitamin D
b) Oxalates
c) Parathyroid Hormone
d) Lactose

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10. Which of the following vitamins does not play a beneficial role in
protecting the biological membranes from lipid peroxidation.
a) Vitamin E
b) Vitamin C
c) Vitamin-B12

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d) Vitamin A
11. Proteins take part in ETC & Oxidative Phosphorylation are coded by
_____
a) Nuclear DNA
b) Mitochndrial DNA

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c) RNA
d) A & B Both
12. Which of the following substance cannot pass through the normal
glomerular membrane?
a) Creatinine

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b) Albumin
c) Myoglobin
d) Uric acid
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13. Which of the following metabolic pathway is amphibolic in nature?
a) Glycolysis
b) Glycogenolysis
c) De-novo synthesis

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d) TCA cycle
14. Following is the major organ involve in metabolism of Xenobiotics
a) Brain
b) Liver
c) Muscles

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d) Kidney
15. Key enzymes of gluconeogenesis except all are
a) Pyruvate carboxylase
b) PEP-CK
c) Fructose 1-6-bisphosphatase

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d) Transketolase
16. Bronze diabetes is associated with
a) Wilson's disease
b) Hemosiderosis
c) Hemochromatosis

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d) Iron deficiency anemia
17. The following is used in measuring GFR
a) Cellulose
b) Inulin
c) Starch

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d) Glycogen
18. Most of glycogen stores are present in
a) Liver
b) Skeletal Muscle
c) Brain

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d) Adipose Tissue
19. Molecule that acts as a local Hormone
a) Phospholipids
b) Cholesterol
c) Prostaglandins

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d) Acetylcholine
20. Dipalmitoyl lecithin acts as:
a) Platelet activating factor
b) Second messenger for hormones
c) Lung surfactant

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d) Anti-ketogenic compound

SECTION-B

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Q.2 Long Answer Questions (2 out of 3)
20
1. Enumerate the beta-oxidation of palmitic acid with energetics. Describe
the regulation of beta oxidation.(2+5+3=10 marks)
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2. Describe the sources, daily requirement, biological functions and
disorders of iron metabolism. Describe the absorption of iron with
enhancing and hindering factors.(1+2+2+2+3=10 marks)

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3. Describe the synthesis and breakdown of glycogen. Describe its
regulation and add a note on glycogen storage
disorders.(4+2+4=10marks)
Q.3 Short Answer Questions (10 out of 11)
20

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1. Give any four examples of phase 1 detoxification reactions.
2. Why is sample for blood glucose collected in fluoride bulb?
3. Why is hypocalcemia seen in Vit D deficiency?
4. Why mitochondria are called powerhouses of the cell?
5. Difference between primary and secondary hypothyroidism on lab

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testing.
6. Biological role of prostacyclins and thromboxane.
7. How do statins help in lowering cholesterol levels?
8. Name essential fatty acids and describe deficiency symptoms.
9. Significance of HMP shunt.

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10. Products formed from cholesterol in the body.
11. Factors causing methaemoglobinemia and its treatment.

SECTION-C

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Q.4 Short Answer Questions (4 out of 5)
20
1. Inhibitors of electron transport chain.
2. Write the role of doctor in healthcare system.

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3. Describe transport across cell membrane.
4. Renal function tests.
5. Amphibolic role of TCA Cycle
Q.5 Clinical Cases (2 out of 2)
20

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Case-1:
A 4-year child was brought to pediatric OPD with edema over legs and face. She
also had discoloration of hair, skin and retarded growth, on enquiring by doctor,
mother told to the doctor that child was on breast milk only for one and half year
of the age and for the last two years she was being given rice. The child was

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admitted in pediatric ward and diagnosed as Protein Energy Malnutrition (PEM).
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The laboratory data of child showed hypoalbuminemia and abdominal

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sonography showed enlarged liver (fatty liver).
1. What are the different types of Protein Energy Malnutrition (PEM)? What
is the type of PEM in this case?
2. What are the clinical features of different type of PEM?
3. What is the cause of edema in this case?

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4. What dietary advice will you suggest for this patient?
5. Why there is fatty liver in PEM?
Case-2:
A 54-year-old obese person presented in emergency with altered consciousness
level and shortness of breath for last 4 hours. He is having history of uncontrolled

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diabetes mellitus for 15 years, as he was not following any medical advice from
physician. Patient's relative told that was also having complained of fever, nausea
& vomiting. On examination physician noted dryness of mouth, pale & dry
conjunctive, sunken eye ball, feeble pulse, tachypnoea, tachycardia, very low
blood pressure (70/40 mm Hg).

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Lab investigations:
Random Blood glucose: 480 mg/dl (70-140 mg/dl)
Blood pH: 7.20 (7.35 ? 7.45)
Serum creatinine: 2.5 mg/dl (0.4-1.4 mg/dl)
Urine glucose: Positive (++++),

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Serum Na+ 120mmol/L (135-145 mmol/L)
Urine Ketones: Positive
Serum K+: 6.0 mmol/l (3.5-5.0 mmol/L)
The patient was diagnosed as a case of Diabetic ketoacidosis with acute renal
failure.

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Questions:
1. Write biochemical basis for shortness of breath and dehydration in this
patient.
2. Ketogenesis occurs only in liver but hepatocytes cannot utilize ketone
bodies. Justify.

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3. Write four causes for positive benedict test in urine other than reducing
sugar.
4. Which other investigation are required for evaluation of renal function &
to differentiate acute & chronic renal failure?
5. Why serum K+ levels have to be monitored while giving the treatment to

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this patient?
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