Download GTU B.Pharma 2018 Summer 1st Sem 818804 Pharmaceutical Organic Chemistry Question Paper

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Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY
Pharm D — 1^st Year EXAMINATION - SUMMER - 2018
Subject Code: 818804
Subject Name: Pharmaceutical Organic Chemistry

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Instructions:

1. Attempt any five questions.

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2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. (a) Classify Intramolecular Forces and Explain Bond dissociation Energy. 06
   (b) Explain Following Terms 04
   1. Heterolysis
   2. Homolysis

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   3. Dipole-Dipole interaction
   4. Polarity of bond
   (c) Explain the reactivity and stability of free radical. 04
2. (a) Discuss the mechanism and stereochemistry of SN1 AND SN2 reaction. 06
   (b) Write a note on Carbocations with mechanism. 04
   

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   (c) Write a note on: Methods of preparation of cycloalkanes. 04
3. (a) Explain the influence of activating and deactivating groups on the electrophillic substitution of benzene. 06
   (b) Explain oxidation-reduction reaction with examples. 04
   (c) Give chemical structure and IUPAC name of following 04
   2,2,4-Trimethylpentane, 1-methoxy-2-propanol, 2-Nitrophenol, Vinyl bromide

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4. (a) Give the preparation, test-of purity, assay and medicinal use of 06
   1. chlorbutol
   2. Sodium lauryl sulphate.
   (b) Differentiate E1 and E2 reaction. 04
   (c) Explain the halohydrin formation. 04
5. (a) Explain the following: 06
   1. aldol condensation

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   2. Sandmeyer’s reaction
   (b) Explain the cycloaddition reaction. 04
   (c) Explain the resonance and hyper-conjugation. 04
6. (a) Comment on the following 06
   1. Meta nitro benzoic acid is more acidic than Para nitro benzoic Acid
   2. Pyridine is aromatic

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   3. All Lowrie-Bronsted acids and bases can be Lewis acids and bases but all Lewis acids and bases cannot be Lowrie-Bronsted acids and bases
   (b) Write detail note on Nucleophilic substitution bimolecular. 04
   (c) Explain Isomerism in organic compound 04
7. (a) Explain the Perkin condensation and Kolbe reaction. 06
   (b) Write free radical halogenations reaction of alkenes. 04
   

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   (c) Write a note on Markownikov’s rule in detail. 04

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