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Seat No.: Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER-8 EXAMINATION — SUMMER -2018
Subject Code: 280004 Date: 04/05/2018
Subject Name: Pharmaceutical Analysis-1V
Time: 10:30 AM TO 01:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Define Validation? Enlist the analytical method validation parameter. Write in detail about any two validation parameters as per ICH guideline. 06
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(b) Give brief note on GATT and TRIPS. 05
(c) Write short note on Good Laboratory Practice (GLP). 05
Q.2 (a) How X-rays radiations are generated? Describe applications of X-ray diffraction. 06
(b) Explain the principle and applications of Nephelometry 05
(c) Define Bragg’s law and explain it in detail. 05
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Q.3 (a) Explain the principle, instrumentation and applications of super critical fluid Chromatography. 06
(b) Discuss detectors used in HPLC. 05
(c) Draw the instrumentation of HPLC and discuss in detail. 05
Q.4 (a) Draw the instrumentation of GC-MS and discuss in brief about GC-MS. 06
(b) Enlist various detectors used in Gas chromatography. Explain FID in detail. 05
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(c) Explain; Guard columns, C18 column, WCOT and PLOT? 05
Q.5 (a) Describe principle, advantage, disadvantage and applications of HPTLC 06
(b) What is basic principle of partition chromatography? Write brief note on it. 05
(c) Write a short note ion-exchange chromatography. 05
Q.6 (a) Discuss basic principle of Raman spectroscopy in detail. Write applications of it. 06
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(b) What is IPR? What are basic criteria for patentability? Explain it. 05
(c) Write comparison of HPLC vs GC. 05
Q.7 (a) What are the different instruments used for measurement of radioactivity? Give a brief account of them. 06
(b) Describe liquid scintillation system for radionuclide. Write applications of Radio nuclides. 05
(c) Give a brief account on ELISA technique. 05
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This download link is referred from the post: GTU B.Pharma 2018 Summer Question Papers || Gujarat Technological University
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