Download GTU B.Pharma 2018 Summer 3rd Sem 2230004 Pharmaceutical Chemistry Iv (Organic Chemistry I) Question Paper

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Seat No.:

Subject Code: 2230004

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Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B. Pharm. - SEMESTER-3 * EXAMINATION - SUMMER -2018

Subject Name: Pharmaceutical Chemistry-IV (Organic Chemistry - I)

Time: 02:30 PM TO 05:30 PM

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Total Marks: 80

Date: 07/05/2018

Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.

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3. Figures to the right indicate full marks.

1. (a) What are intermolecular forces? Comment on types of intermolecular forces with examples. (06)
2. (b) Explain electro-negativity. Comment polarity of bonds and molecules with examples. (05)
3. (a) Define bonding and anti-bonding orbital’s and explain them in detail. (05)
4. (b) Give reasons for acceptance of Kekules structure of benzene. (06)

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5. (c) What are 1°, 2° & 3° hydrogen atoms? Comment on the ease of abstraction of each type of hydrogen atom. Support your answer with suitable reactions. (05)
6. (a) What are nitrenes and carbenes? Comment on generation and reactions of different types of carbenes. (05)
7. (b) Classify alcohols with examples. Explain Lucas Test. (06)
8. (c) Enlist various reactions for preparation of alcohols. Comment on oxymercuration-demercuration reaction for preparation of alcohols. (05)
9. (a) Classify dienes and comment on stability of allyl radical. (05)

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10. (b) Give three methods for preparation of alkanes with example. (06)
11. (c) What is conformation? Explain conformation of n-butane with potential energy diagram. (05)
12. (a) Explain Saytzeffs rule and Markonikov’s rule with suitable examples. (05)
13. (b) Differentiate between E1 and E2 mechanism with examples. (06)
14. (c) Comment on the following:
    1. Water is liquid while hydrogen sulphide is gas at room temperature

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    2. Tri-chloroacetic acid is more acidic than acetic acid.
    (05)
15. (a) What are geometric isomers? Comment on orientation of double bond in E1 reaction with suitable example. (05)
16. (b) What are nucleophilic substitution reactions? Explain mechanism and stereochemistry of SN2 reactions. (06)
17. (c) What are alkynes? Give any four chemical reactions of alkynes with examples. (05)

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18. (a) Comment on the following:
    1. Pi bonds are weaker than sigma bonds.
    2. Length of carbon-carbon triple bond is smaller than double bond.
    (05)
19. (b) Give structure and IUPAC nomenclature of the following: Allyl alcohol, Isopropyl chloride, Dimethylacetylene, Isobutylene. (06)
20. (c) Explain why primary alkyl halides follow SN2 mechanism of reaction. (05)

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21. (a) Comment in detail on utility of Grignard reactions in organic chemistry. (05)

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