Download GTU B.Pharma 2018 Summer 4th Sem 2240004 Pharmaceutical Chemistry Vi (Organic Chemistry Ii) Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER- IV EXAMINATION - SUMMER 2018

Subject Code: 2240004 Date: 21/05/2018

Subject Name: Pharmaceutical Chemistry-VI (Organic Chemistry-II)

Time: 10:30 AM TO 01:30 PM Total Marks: 80

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Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q1 (a) Draw structure for the following compounds. 06

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1. trans-1-bromo-3-chlorocyclobutane
2. cis-3-chloro-1-butene
3. 2-bromo-4-chloropentane
4. 3-chloro-2-butanol
5. (S)-3-chloro-1-pentanol

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6. (2S,3R)-3-methyl-2-pentanol

(b) Write a Short note on stereochemistry of Biphenyls. 05

(c) Define the following terms: 05

1. Specific Rotation
2. Racemic mixture

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3. Configuration
4. Enantiomer
5. Geometrical isomerism

Q2 (a) Explain the following reactions. 06

1. Kolbe reaction of Phenols

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2. Michael addition

(b) Discuss with mechanism Perkin reaction to synthesize a, ß-unsaturated carbonyl compounds. 05

(c) What are Phenols? How phenols are prepared? 05

Q3 (a) What do you mean by Neucleophilic aromatic substitution reaction? Give mechanism for Elimination —addition reaction for aryl halides. 06

(b) Explain the Hofmann degradation of amides. 05

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(c) Explain the mechanism involved in Aldol condensation. 05

Q4 (a) What do you mean by conformation? Discuss the stability and potential energy changes of all conformations for n-pentane considering bond between C₂ and C₃. 06

(b) How will convert the following. 05

1. Acetophenone to a-Phenyl ethyl alcohol.
2. Benzoyl chloride to Ethyl benzoate

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3. Toluene to Benzylamine
4. Toluene to o-Bromotoluene
5. Nitrobenzene to m-bromophenol

(c) What are Acid derivatives? Discuss the preparation and reactions of Esters. 05

Q5 (a) Discuss the Neucleophilic addition reactions for carbonyl compounds. 06

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(b) What are nano particles? How nano particles are used in Pharmacy. 05

(c) Give the structure of the following compounds: 05

1. 3,5-Dinitrobenzoyl Chloride
2. p-hydroxyphenylacetic acid
3. N,N-Dimethylaminocyclohexane

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4. o-Chloroanisole
5. Ethyl isopropyl ketone

Q.6 (a) What are heterocyclic compounds? Give the preparations and reactions of pyridine. 06

(b) Give the structure of the following. 05

1. Pyrazine

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2. Imidazole
3. Isoquinoline
4. Thiazole
5. Indole

(c) Comment on the following. 05

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1. Electrophilic substitution in Pyrrole occurs at 2^nd position rather than 3^rd position.
2. Thiophene is more basic than furan.

Q.7 (a) Give preparation and reactions of diazonium salt. 06

(b) Write a note on green chemistry. 05

(c) Give applications of microwave synthesis in chemistry. 05

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